Petro Jorge L, Gallo-Villegas Jaime, Calderón Juan C
Physiology and Biochemistry Research Group-PHYSIS, Faculty of Medicine, University of Antioquia, Medellín, Colombia.
Research Group in Physical Activity, Sports and Health Sciences (GICAFS), Universidad de Córdoba, Montería, Colombia.
Front Endocrinol (Lausanne). 2025 Jul 16;16:1557142. doi: 10.3389/fendo.2025.1557142. eCollection 2025.
Myonectin is a myokine with a potential role in metabolic health. This is a bibliometric and bioinformatics-complemented systematic review aimed to comprehensively analyze the structure, regulation and effects of myonectin on metabolic outcomes relevant to the pathophysiology of chronic metabolic diseases. Fifty-three studies involving cellular, animal, and human models were included. Findings indicate that myonectin is induced by aerobic exercise, nutrients, epinephrin, hypoxia and curcumin but is downregulated by obesity and muscle dysfunction. Evidence suggests that myonectin regulates lipid uptake and distribution across tissues, reduces inflammation and apoptosis and modulates mitochondrial function likely through the activation of AKT and AMP-activated protein kinase (AMPK)-mediated signaling pathways. While most results arising from human studies of good quality are in agreement with animal and cellular data, controversy remains and we discuss challenges and perspectives in the field. In conclusion, myonectin has a diverse role in regulating metabolic health, but a key contribution pertains to lipid regulation, which likely leads to a healthy expansion and distribution of adipose tissue.
肌连接蛋白是一种对代谢健康具有潜在作用的肌动蛋白。这是一项文献计量学和生物信息学辅助的系统综述，旨在全面分析肌连接蛋白的结构、调节及其对与慢性代谢疾病病理生理学相关的代谢结果的影响。纳入了53项涉及细胞、动物和人体模型的研究。研究结果表明，有氧运动、营养物质、肾上腺素、缺氧和姜黄素可诱导肌连接蛋白的产生，但肥胖和肌肉功能障碍会使其表达下调。有证据表明，肌连接蛋白可能通过激活AKT和AMP激活蛋白激酶（AMPK）介导的信号通路来调节脂质在组织间的摄取和分布，减轻炎症和细胞凋亡，并调节线粒体功能。虽然大多数高质量的人体研究结果与动物和细胞数据一致，但仍存在争议，我们讨论了该领域的挑战和前景。总之，肌连接蛋白在调节代谢健康方面具有多种作用，但其关键作用在于脂质调节，这可能导致脂肪组织的健康扩张和分布。
