信使核糖核酸疫苗面临免疫耐受问题。 - Suppr

mRNA vaccines take on immune tolerance.

作者信息

Wardell Christine M, Levings Megan K

机构信息

BC Children's Hospital Research Institute and Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada.

出版信息

Nat Biotechnol. 2021 Apr;39(4):419-421. doi: 10.1038/s41587-021-00880-0.

DOI:10.1038/s41587-021-00880-0

PMID:33785909

Abstract

摘要

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mRNA vaccines take on immune tolerance.信使核糖核酸疫苗面临免疫耐受问题。

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Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA.用负载有 MOG 编码 mRNA 的耐受原性树突状细胞控制实验性自身免疫性脑脊髓炎的临床和免疫

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Dose-dependent mechanisms relate to nasal tolerance induction and protection against experimental autoimmune encephalomyelitis in Lewis rats.剂量依赖性机制与Lewis大鼠鼻内耐受诱导及实验性自身免疫性脑脊髓炎的保护作用相关。

Immunology. 1998 Jul;94(3):431-7. doi: 10.1046/j.1365-2567.1998.00526.x.

FURTHER STUDIES OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN THE FOWL. IV. THE SUPPRESSION OF THE EXPERIMENTAL LESIONS BY A NATURALLY OCCURRING NEURITIS.禽类实验性变应性脑脊髓炎的进一步研究。IV. 自然发生的神经炎对实验性病变的抑制作用

Res Vet Sci. 1965 Jul;6:324-9.

Mice resistant to experimental autoimmune encephalomyelitis have increased thymic expression of myelin basic protein and increased MBP specific T cell tolerance.对实验性自身免疫性脑脊髓炎具有抗性的小鼠，其胸腺中髓鞘碱性蛋白的表达增加，且髓鞘碱性蛋白特异性T细胞耐受性增强。

J Neuroimmunol. 2001 Apr 2;115(1-2):118-26. doi: 10.1016/s0165-5728(01)00269-7.

Nasal administration of myelin basic protein prevents relapsing experimental autoimmune encephalomyelitis in DA rats by activating regulatory cells expressing IL-4 and TGF-beta mRNA.髓鞘碱性蛋白经鼻腔给药可通过激活表达白细胞介素-4和转化生长因子-β信使核糖核酸的调节细胞，预防DA大鼠复发性实验性自身免疫性脑脊髓炎。

J Neuroimmunol. 1997 Dec;80(1-2):65-75. doi: 10.1016/s0165-5728(97)00133-1.

Suppression of experimental autoimmune myasthenia gravis and experimental allergic encephalomyelitis by oral administration of acetylcholine receptor and myelin basic protein: double tolerance.口服乙酰胆碱受体和髓鞘碱性蛋白对实验性自身免疫性重症肌无力和实验性变应性脑脊髓炎的抑制作用：双重耐受

J Neuroimmunol. 1995 Dec;63(1):79-86. doi: 10.1016/0165-5728(95)00136-0.

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A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis.一种用于治疗实验性自身免疫性脑脊髓炎的非炎症性 mRNA 疫苗。

Science. 2021 Jan 8;371(6525):145-153. doi: 10.1126/science.aay3638.

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N Engl J Med. 2020 Dec 31;383(27):2603-2615. doi: 10.1056/NEJMoa2034577. Epub 2020 Dec 10.

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates.两种基于 RNA 的新冠候选疫苗的安全性和免疫原性。

N Engl J Med. 2020 Dec 17;383(25):2439-2450. doi: 10.1056/NEJMoa2027906. Epub 2020 Oct 14.

Antigen-specific therapeutic approaches for autoimmunity.针对自身免疫的抗原特异性治疗方法。

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Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy.系统性 RNA 递送至树突状细胞利用抗病毒防御机制进行癌症免疫治疗。

Nature. 2016 Jun 16;534(7607):396-401. doi: 10.1038/nature18300. Epub 2016 Jun 1.

The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets.多发性硬化症的靶抗原研究，第 1 部分：自身反应性 CD4+T 淋巴细胞作为致病效应物和治疗靶点。

Lancet Neurol. 2016 Feb;15(2):198-209. doi: 10.1016/S1474-4422(15)00334-8. Epub 2015 Dec 24.

mRNA-based therapeutics--developing a new class of drugs.mRNA 疗法——开发一类新药。

Nat Rev Drug Discov. 2014 Oct;13(10):759-80. doi: 10.1038/nrd4278. Epub 2014 Sep 19.

Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability.将假尿苷掺入mRNA可产生具有更高翻译能力和生物稳定性的优质非免疫原性载体。

Mol Ther. 2008 Nov;16(11):1833-40. doi: 10.1038/mt.2008.200. Epub 2008 Sep 16.

Induction of antigen-specific tolerance in multiple sclerosis after immunization with DNA encoding myelin basic protein in a randomized, placebo-controlled phase 1/2 trial.在一项随机、安慰剂对照的1/2期试验中，用编码髓鞘碱性蛋白的DNA免疫后诱导多发性硬化症患者产生抗原特异性耐受性。

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Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA.Toll样受体对RNA识别的抑制作用：核苷修饰的影响及RNA的进化起源

Immunity. 2005 Aug;23(2):165-75. doi: 10.1016/j.immuni.2005.06.008.

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mRNA vaccines take on immune tolerance.

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