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mRNA vaccines take on immune tolerance.

作者信息

Wardell Christine M, Levings Megan K

机构信息

BC Children's Hospital Research Institute and Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada.

出版信息

Nat Biotechnol. 2021 Apr;39(4):419-421. doi: 10.1038/s41587-021-00880-0.

DOI:10.1038/s41587-021-00880-0
PMID:33785909
Abstract
摘要

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Dose-dependent mechanisms relate to nasal tolerance induction and protection against experimental autoimmune encephalomyelitis in Lewis rats.剂量依赖性机制与Lewis大鼠鼻内耐受诱导及实验性自身免疫性脑脊髓炎的保护作用相关。
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A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis.一种用于治疗实验性自身免疫性脑脊髓炎的非炎症性 mRNA 疫苗。
Science. 2021 Jan 8;371(6525):145-153. doi: 10.1126/science.aay3638.
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Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.BNT162b2 mRNA 新冠病毒疫苗的安全性和有效性。
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Vaccines for immune tolerance against autoimmune disease.针对自身免疫性疾病的免疫耐受疫苗。
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Opposite Effects of mRNA-Based and Adenovirus-Vectored SARS-CoV-2 Vaccines on Regulatory T Cells: A Pilot Study.基于mRNA和腺病毒载体的新型冠状病毒疫苗对调节性T细胞的相反作用：一项初步研究。
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Lipid Nanoparticles for mRNA Delivery to Enhance Cancer Immunotherapy.用于 mRNA 递送至增强癌症免疫疗法的脂质纳米颗粒。
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Noncoding-RNA-Based Therapeutics with an Emphasis on Prostatic Carcinoma-Progress and Challenges.基于非编码RNA的疗法，重点关注前列腺癌——进展与挑战
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Antigen-specific therapeutic approaches for autoimmunity.针对自身免疫的抗原特异性治疗方法。
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Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy.系统性 RNA 递送至树突状细胞利用抗病毒防御机制进行癌症免疫治疗。
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