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DAT 联合 VSD 技术在大鼠创面修复中的分析及其对炎症因子的影响。

Analysis of DAT Combined with the VSD Technique in Wound Repair of Rats and Its Effect on Inflammatory Factors.

机构信息

Department of Burns and Plastic Surgery, The 940th Hospital of Joint Logistics Support Force of Chinese PLA, Lanzhou 730050, China.

出版信息

Contrast Media Mol Imaging. 2022 Aug 20;2022:2662876. doi: 10.1155/2022/2662876. eCollection 2022.

DOI:10.1155/2022/2662876
PMID:36072624
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9420065/
Abstract

The clinical efficacy of decellularized adipose tissue (DAT) combined with vacuum sealing drainage (VSD) in the treatment of wound healing in rats is investigated, and the changes of inflammatory factors are analyzed. The tissue defect model of SD (Sprague-Dawley) rats is established and divided into the combined group ( = 12) and the control group ( = 12) according to different treatment methods. The control group is treated with a single VSD technique, and the combined group is treated with DAT on the basis of the control group. The wound healing time of the two groups is observed. Wound tissue is collected 1 day, 10 days, 20 days, and 30 days after treatment, and neutrophil infiltration is observed by HE (hematoxylin-eosin) staining. The expression changes of IL-6 and IL-13 at each time point before and after treatment are compared. Histological observation shows that the cell infiltration is reduced in both groups, and the wound repair in the combined group is better than that in the control group. The experimental results show that the DAT combined with the VSD technique can further speed up wound healing and reduce inflammation in rats.

摘要

研究脱细胞脂肪组织（DAT）联合真空密封引流（VSD）治疗大鼠创面愈合的临床疗效，并分析炎症因子的变化。建立 SD（Sprague-Dawley）大鼠组织缺损模型，根据不同的治疗方法分为联合组（n=12）和对照组（n=12）。对照组采用单纯 VSD 技术治疗，联合组在对照组基础上采用 DAT 治疗。观察两组的伤口愈合时间。治疗后 1 天、10 天、20 天和 30 天采集创面组织，HE（苏木精-伊红）染色观察中性粒细胞浸润情况。比较治疗前后各时间点 IL-6 和 IL-13 的表达变化。组织学观察发现，两组细胞浸润减少，联合组的创面修复情况优于对照组。实验结果表明，DAT 联合 VSD 技术可进一步加快大鼠创面愈合，减轻炎症反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f86d/9420065/b7e92f3aabaa/CMMI2022-2662876.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f86d/9420065/9a99c777826b/CMMI2022-2662876.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f86d/9420065/390d6eb10854/CMMI2022-2662876.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f86d/9420065/6806ec66765d/CMMI2022-2662876.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f86d/9420065/c4b7570c332c/CMMI2022-2662876.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f86d/9420065/1681993d48df/CMMI2022-2662876.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f86d/9420065/b6a8e4b04d50/CMMI2022-2662876.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f86d/9420065/89078f5821d5/CMMI2022-2662876.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f86d/9420065/da9853100611/CMMI2022-2662876.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f86d/9420065/b7e92f3aabaa/CMMI2022-2662876.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f86d/9420065/9a99c777826b/CMMI2022-2662876.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f86d/9420065/390d6eb10854/CMMI2022-2662876.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f86d/9420065/6806ec66765d/CMMI2022-2662876.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f86d/9420065/c4b7570c332c/CMMI2022-2662876.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f86d/9420065/1681993d48df/CMMI2022-2662876.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f86d/9420065/b6a8e4b04d50/CMMI2022-2662876.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f86d/9420065/89078f5821d5/CMMI2022-2662876.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f86d/9420065/da9853100611/CMMI2022-2662876.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f86d/9420065/b7e92f3aabaa/CMMI2022-2662876.009.jpg

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Contrast Media Mol Imaging. 2023 Jul 19;2023:9841635. doi: 10.1155/2023/9841635. eCollection 2023.

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Furnishing Wound Repair by the Subcutaneous Fascia.皮下筋膜提供伤口修复。
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Decellularized adipose tissue scaffolds guide hematopoietic differentiation and stimulate vascular regeneration in a hindlimb ischemia model.
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