Department of Endocrinology and Diabetology, Children's Memorial Health Institute, Warsaw, Poland.
Department of Ophthalmology, Children's Memorial Health Institute, Warsaw, Poland.
Diab Vasc Dis Res. 2021 Mar-Apr;18(2):14791641211004427. doi: 10.1177/14791641211004427.
This study aimed to assess the influence of pubertal status on the results of optical coherence tomography angiography (OCTA) in children with type 1 diabetes (T1D).
We enrolled 167 consecutive children with T1D. Retinal superficial capillary plexus (SCP) and deep capillary plexus (DCP) vessel density data underwent analysis. We divided the study population into three subgroups depending on the pubertal status.
Analysis of the prepubertal and pubertal subgroups revealed statistically significant differences in foveal thickness (FT) (p < 0.05) and foveal SCP (p < 0.02). Analyzing subgroups of the prepubertal and postpubertal children, we observed statistically significant differences in FT (p < 0.03), whole SCP (p < 0.02), and foveal SCP (p < 0.02). Comparison of the pubertal and postpubertal subjects revealed differences in parafoveal DCP (p < 0.003). In the groups matched depending on diabetes duration, we observed differences between prepubertal, pubertal, and postpubertal children in FT, PFT, and parafoveal SCP and DCP.
Our data suggest that in a cohort of pubertal children with a short duration of diabetes, alterations in retinal vessel density occur early and progress during puberty.
本研究旨在评估青春期状态对 1 型糖尿病（T1D）患儿光学相干断层扫描血管造影（OCTA）结果的影响。
我们纳入了 167 例连续的 T1D 患儿。对视网膜浅层毛细血管丛（SCP）和深层毛细血管丛（DCP）血管密度数据进行了分析。我们根据青春期状态将研究人群分为三个亚组。
对青春期前和青春期亚组的分析显示，黄斑中心凹厚度（FT）（p<0.05）和黄斑中心凹 SCP（p<0.02）存在统计学显著差异。分析青春期前和青春期后儿童的亚组，我们观察到 FT（p<0.03）、全 SCP（p<0.02）和黄斑中心凹 SCP（p<0.02）存在统计学显著差异。青春期和青春期后受试者之间的比较显示，旁中心凹 DCP 存在差异（p<0.003）。在根据糖尿病病程匹配的组中，我们观察到青春期前、青春期和青春期后儿童在 FT、PFT 和旁中心凹 SCP 和 DCP 方面存在差异。
我们的数据表明，在糖尿病病程较短的青春期儿童队列中，视网膜血管密度的改变发生较早，并在青春期进展。
