Department of Endocrinology.
Department of Respiratory Medicine, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Medicine (Baltimore). 2021 Apr 2;100(13):e25303. doi: 10.1097/MD.0000000000025303.
This study aimed to investigate the association between mean platelet volume (MPV) and metabolic syndrome (MetS) in patients with type 2 diabetes mellitus (T2DM). Data for 1240 patients with T2DM admitted to the Department of Endocrinology at the First Affiliated Hospital of Guangxi Medical University between January 1, 2017 and June 1, 2020 were collected retrospectively via electronic medical records, including demographic information, complete blood count, lipid profile, and glucose metabolism indexes. MetS was defined according to the Chinese Diabetes Society. Among the 1240 patients enrolled, 873 (70.40%) had MetS. MPV was significantly higher in patients with MetS (P < .001). For individual MetS components, MPV was significantly higher in the presence of abdominal obesity (P = .013) and hypertriglyceridemia (P = .026), but did not differ in the presence of elevated blood pressure (P = .330) or low high-density lipoprotein cholesterol (P = .790). Moreover, MPV was independently associated with MetS after adjustment for sex, smoking, alcohol drinking, white blood cell count, fasting C-peptide, and body mass index (odds ratio 1.174, 95% confidence interval 1.059-1.302). The odds ratio for MetS in the highest tertile, compared with the lowest MPV tertile, was 1.724 (95% confidence interval 1.199-2.479, P for trend = .003) after multiple adjustment. In stratified analyses, the positive correlation of MPV with MetS was significant only in patients who were older, male, or overweight, or who had poor glycemic control. In conclusion, high MPV was positively associated with the presence of MetS in patients with T2DM, particularly older, male, or overweight patients, or those with poor glycemic control.
本研究旨在探讨 2 型糖尿病（T2DM）患者平均血小板体积（MPV）与代谢综合征（MetS）之间的关系。通过电子病历回顾性收集了 2017 年 1 月 1 日至 2020 年 6 月 1 日期间广西医科大学第一附属医院内分泌科收治的 1240 例 T2DM 患者的数据，包括人口统计学信息、全血细胞计数、血脂谱和葡萄糖代谢指标。MetS 根据中国糖尿病协会的标准定义。在纳入的 1240 例患者中，873 例（70.40%）患有 MetS。MPV 在患有 MetS 的患者中明显更高（P < 0.001）。对于个别 MetS 成分，MPV 在存在腹型肥胖时明显更高（P = 0.013），而在存在高血压时没有差异（P = 0.330）或低高密度脂蛋白胆固醇（P = 0.790）。此外，MPV 在调整性别、吸烟、饮酒、白细胞计数、空腹 C 肽和体重指数后与 MetS 独立相关（比值比 1.174，95%置信区间 1.059-1.302）。与最低 MPV 三分位相比，最高三分位 MetS 的比值比为 1.724（95%置信区间 1.199-2.479，趋势检验 P = 0.003）。在分层分析中，MPV 与 MetS 的正相关性仅在年龄较大、男性或超重或血糖控制较差的患者中显著。总之，在 T2DM 患者中，高 MPV 与 MetS 的存在呈正相关，尤其是年龄较大、男性或超重或血糖控制较差的患者。
