Kelem Amanuel, Adane Tiruneh, Shiferaw Elias
Department of Medical Laboratory Sciences, Asrat Woldeyes Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia.
Department of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Diabetes Metab Syndr Obes. 2023 Sep 18;16:2843-2853. doi: 10.2147/DMSO.S425469. eCollection 2023.
Insulin has an inhibitory effect on platelets; however, this is compromised in circumstances of Insulin Resistance (IR), leading to platelet hyperactivity. Platelet parameters such as mean platelet volume, platelet count, and platelet distribution width are simple and accessible potential biomarkers for the early diagnosis and prognosis of IR. Therefore, the aim of this review is to provide insight on the current status of knowledge regarding IR-induced platelet hyperactivation and the potential biomarker role of platelet parameters.
This narrative review included articles published in the English language. Searches were carried out at the electronic databases PubMed and Google Scholar. The search strategy was done by combining key words and related database-specific subject terms (Mesh terms) with the appropriate Boolean operators.
Increasing insulin sensitivity in insulin resistant patients would possibly cause substantial reduction in platelet activation, which in turn reduce complications related with platelet hyperactivation. The standard methods to measure IR are not frequently employed in clinical practice due to their expensiveness and complexity. Thus, early detection of IR using a simple and more widely available biomarkers such as mean platelet volume, platelet count and platelet distribution width would be beneficial. Particularly in developing countries where resource scarcity is a major constraint of the health sector, utilizing such easy and affordable biomarkers may have a crucial role.
胰岛素对血小板具有抑制作用；然而，在胰岛素抵抗（IR）情况下这种作用会受到损害，导致血小板活性亢进。血小板参数如平均血小板体积、血小板计数和血小板分布宽度是用于IR早期诊断和预后的简单且可获取的潜在生物标志物。因此，本综述的目的是深入了解关于IR诱导的血小板过度活化以及血小板参数潜在生物标志物作用的当前知识状况。
本叙述性综述纳入了以英文发表的文章。在电子数据库PubMed和谷歌学术上进行了检索。通过将关键词和相关数据库特定主题词（医学主题词）与适当的布尔运算符相结合来制定检索策略。
提高胰岛素抵抗患者的胰岛素敏感性可能会使血小板活化大幅降低，进而减少与血小板过度活化相关的并发症。由于测量IR的标准方法昂贵且复杂，在临床实践中并不常用。因此，使用平均血小板体积、血小板计数和血小板分布宽度等简单且更易获得的生物标志物早期检测IR将是有益的。特别是在资源稀缺是卫生部门主要制约因素的发展中国家，利用此类简便且经济实惠的生物标志物可能具有关键作用。
