Department of Human Nutrition and Metabolomics, Pomeranian Medical University, Szczecin, Poland.
Department of Applied Neurocognitivistic, Pomeranian Medical University, Szczecin, Poland.
Eur J Nutr. 2021 Aug;60(5):2275-2291. doi: 10.1007/s00394-021-02489-0. Epub 2021 Mar 31.
Non-specific inflammatory bowel diseases (IBD) include Crohn's disease and ulcerative colitis. More and more often attention is paid to the possibility of dietary support for inflammatory bowel diseases.
The following review article considers the role of dietary components in the treatment of IBD as: pteridines, probiotics, bovine immunoglobulin, vitamin D, omega-3, flavonoids, polyphenols, curcumin and phosphatidylcholine. The article also discusses plant raw materials of arjuna, soy protein and nettles, trying to summarize their effect on quenching the inflammatory process within the intestines. This review focuses on the possibilities of dietary components and supplementation use to improve the pharmacotherapy response as well as the general clinical patients' condition.
The mechanism of action of supportive therapy is based on reduction in oxidative stress, maintaining the adequate balance between Th1 and Th2 lymphocytes by affecting cytokines, increasing riboflavin supply for macrophages, increasing expression of vitamin D receptor, regulation by decreasing the expression of NF-κB in liver cells and ability to inhibit the COX2 entrance and inactivate prostaglandins that are involved in the inflammatory process and 12-lipoxygenase pathway inhibition.
Considering clinical researches, it seems that the use of the above-mentioned ingredients in the diet of patients suffering IBD may positively influence the treatment process and maintenance of remission.
非特异性炎症性肠病（IBD）包括克罗恩病和溃疡性结肠炎。越来越多的人开始关注饮食对炎症性肠病的支持作用。
本文综述了饮食成分在 IBD 治疗中的作用，包括蝶呤、益生菌、牛免疫球蛋白、维生素 D、ω-3、类黄酮、多酚、姜黄素和磷脂酰胆碱。本文还讨论了诃子、大豆蛋白和荨麻等植物原料，试图总结它们对抑制肠道内炎症过程的作用。本文重点讨论了饮食成分和补充剂的使用，以改善药物治疗反应以及改善患者的一般临床状况。
支持治疗的作用机制基于减少氧化应激，通过影响细胞因子来维持 Th1 和 Th2 淋巴细胞之间的适当平衡，增加巨噬细胞的核黄素供应，增加维生素 D 受体的表达，通过减少肝细胞中 NF-κB 的表达来调节，并抑制参与炎症过程的 COX2 进入和失活前列腺素以及 12-脂氧合酶途径的抑制。
考虑到临床研究，IBD 患者饮食中使用上述成分似乎可以积极影响治疗过程和缓解期的维持。
