Asero R, D'Agostino P, Bertetti E, Origgi L, Riboldi P
Istituto di Medicina Interna, Università degli Studi di Milano, Italia.
Immunol Lett. 1988 May;18(1):1-3. doi: 10.1016/0165-2478(88)90060-0.
In a clinical and serological study performed on a large series of patients with different connective tissue diseases, anti-ribosomal ribonucleoprotein (rRNP) antibodies were detected only in a small proportion of sera with systemic lupus erythematosus (SLE). SLE patients positive for anti-rRNP autoantibodies showed a significantly higher incidence of hemolytic anemia. The reasons for this surprising association are still unclear; however, this finding suggests that rRNP precipitin might be considered as a useful marker of a particular subgroup of patients with SLE.
在一项针对大量患有不同结缔组织疾病患者的临床和血清学研究中，仅在一小部分系统性红斑狼疮（SLE）患者的血清中检测到抗核糖体核糖核蛋白（rRNP）抗体。抗rRNP自身抗体呈阳性的SLE患者溶血性贫血的发病率显著更高。这种惊人关联的原因仍不清楚；然而，这一发现表明rRNP沉淀素可能被视为SLE特定亚组患者的有用标志物。
