Polloni A, Marchi S, Greco A, Cipparrone G, Costa F, Bellini M, Maltinti G
First Medical Clinic, University of Pisa, Italy.
Int J Clin Pharmacol Res. 1988;8(2):139-42.
Twenty patients affected with endoscopically demonstrated duodenal ulcer were studied. They were randomly divided into two groups of ten individuals each. The first group was treated with famotidine 40 mg/die/os, the second one with cimetidine 800 mg/die/os; both drugs were administered in one medication at bedtime. In each group, eight patients completed the treatment: six out of eight famotidine treated and five out of eight cimetidine treated patients showed ulcer healing on upper digestive endoscopy after four weeks of treatment; after eight weeks of therapy, all patients of both groups displayed ulcer healing. Nevertheless, an overall quantitative evaluation of all peptic lesions (performed according to an endoscopic arbitrary score) indicated a higher effectiveness of famotidine. Famotidine did not affect humoral parameters of renal, hepatic and myelopoietic function and did not significantly change fasting serum gastrin levels.
对20例经内镜证实患有十二指肠溃疡的患者进行了研究。他们被随机分为两组，每组10人。第一组接受法莫替丁治疗，剂量为40毫克/天，口服；第二组接受西咪替丁治疗，剂量为800毫克/天，口服；两种药物均在睡前一次服用。每组中，8名患者完成了治疗：接受法莫替丁治疗的8名患者中有6名，接受西咪替丁治疗的8名患者中有5名在治疗4周后上消化道内镜检查显示溃疡愈合；治疗8周后，两组所有患者均显示溃疡愈合。然而，对所有消化性病变进行的总体定量评估（根据内镜任意评分进行）表明法莫替丁的疗效更高。法莫替丁不影响肾脏、肝脏和骨髓造血功能的体液参数，也未显著改变空腹血清胃泌素水平。
