Smith M D, Bielawska C, Kelsey M C, Rai G, Deaney N B
Department of Microbiology, Whittington Hospital, London, UK.
J Antimicrob Chemother. 1988 Apr;21(4):481-7. doi: 10.1093/jac/21.4.481.
Eighty-seven episodes of infection occurring in 83 patients were treated with imipenem as the sole antibiotic (1.5-4 g daily). All patients were aged 65 years or over, many with other non-infective diseases. A favourable clinical outcome (infection cured or improved) was obtained in 88% of cases. Of the 37 patients who were microbiologically evaluable, a favourable clinical outcome occurred in 92% and a favourable bacteriological outcome (pathogen eradicated or suppressed) occurred in 86% of cases. There were 13 deaths amongst the study group, which might be expected in an ill elderly population. None of the deaths was thought attributable to imipenem. Minor clinical side effects occurred in 10.6%, and one patient sustained a cerebral ischaemic episode and fits, possibly related to imipenem. No serious changes were detected in laboratory parameters.
83例患者发生了87次感染发作，使用亚胺培南作为唯一抗生素进行治疗（每日1.5 - 4克）。所有患者年龄均在65岁及以上，许多人还患有其他非感染性疾病。88%的病例获得了良好的临床结果（感染治愈或改善）。在37例可进行微生物学评估的患者中，92%的病例获得了良好的临床结果，86%的病例获得了良好的细菌学结果（病原体被根除或抑制）。研究组中有13例死亡，在患病的老年人群中这可能是预期的。没有一例死亡被认为归因于亚胺培南。10.6%的患者出现了轻微的临床副作用，一名患者发生了脑缺血发作和癫痫，可能与亚胺培南有关。实验室参数未检测到严重变化。
