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影响范围：以鼠、人为模型，看微生物模拟人类感染的程度如何？

mSphere of Influence: Of Mice, Men, and Microbes-How Well Do Experimental Models Recapitulate Human Infection?

机构信息

Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA

出版信息

mSphere. 2021 Mar 31;6(2):e00228-21. doi: 10.1128/mSphere.00228-21.

DOI:10.1128/mSphere.00228-21
PMID:33789942
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8546702/
Abstract

Chelsie Armbruster studies catheter-associated urinary tract infection and the contribution of microbe-microbe interactions to infection progression and severity. In this mSphere of Influence article, she reflects on how two papers, A. E. Frick-Cheng, A. Sintsova, S. N. Smith, M. Krauthammer, et al., mBio 11:e01412-20, 2020, https://doi.org/10.1128/mBio.01412-20, and D. M. Cornforth, F. L. Diggle, J. A. Melvin, J. M. Bomberger, and M. Whiteley, mBio 11:e03042-19, 2020, https://doi.org/10.1128/mBio.03042-19, have impacted her thinking about the bacterial strains and experimental models used to study pathogenesis.

摘要

切尔西·阿姆布拉斯特研究导管相关性尿路感染，以及微生物-微生物相互作用对感染进展和严重程度的影响。在这篇《mSphere 影响力》文章中，她反思了两篇论文，A.E. 弗里克-郑、A. 辛茨娃、S.N. 史密斯、M. 克拉特哈默等人在《mBio》上发表的 2020 年第 11 期论文“Microbiota-Derived Compounds that Inhibit Staphylococcus aureus Virulence”和 D.M. 康福思、F.L. 迪格利、J.A. 梅尔文、J.M. 邦伯格和 M. 怀特利在《mBio》上发表的 2020 年第 11 期论文“Enterococcus faecalis Biofilms Are Protected from Host Defense by a pH-Responsive Diffusible Signal Factor”，这两篇论文如何影响她对研究发病机制所用细菌株和实验模型的思考。

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本文引用的文献

1
The Gene Expression Profile of Uropathogenic Escherichia coli in Women with Uncomplicated Urinary Tract Infections Is Recapitulated in the Mouse Model.尿路致病性大肠埃希菌在单纯性尿路感染女性中的基因表达谱在小鼠模型中重现。
mBio. 2020 Aug 11;11(4):e01412-20. doi: 10.1128/mBio.01412-20.
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Transposon Insertion Site Sequencing of Providencia stuartii: Essential Genes, Fitness Factors for Catheter-Associated Urinary Tract Infection, and the Impact of Polymicrobial Infection on Fitness Requirements.斯氏普罗威登斯菌转座子插入位点测序：必需基因、与导尿管相关的尿路感染适应因子，以及混合感染对适应要求的影响。
mSphere. 2020 May 27;5(3):e00412-20. doi: 10.1128/mSphere.00412-20.
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Quantitative Framework for Model Evaluation in Microbiology Research Using and Cystic Fibrosis Infection as a Test Case.使用 定量框架评估微生物研究模型——以囊性纤维化感染为例。
mBio. 2020 Jan 14;11(1):e03042-19. doi: 10.1128/mBio.03042-19.
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Genome-wide transposon mutagenesis of Proteus mirabilis: Essential genes, fitness factors for catheter-associated urinary tract infection, and the impact of polymicrobial infection on fitness requirements.奇异变形杆菌的全基因组转座子诱变：必需基因、导管相关性尿路感染的适应性因子以及混合感染对适应性需求的影响。
PLoS Pathog. 2017 Jun 14;13(6):e1006434. doi: 10.1371/journal.ppat.1006434. eCollection 2017 Jun.
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Co-infecting microorganisms dramatically alter pathogen gene essentiality during polymicrobial infection.共感染微生物在混合感染期间显著改变病原体基因的必需性。
Nat Microbiol. 2017 May 30;2:17079. doi: 10.1038/nmicrobiol.2017.79.
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The Pathogenic Potential of Proteus mirabilis Is Enhanced by Other Uropathogens during Polymicrobial Urinary Tract Infection.奇异变形杆菌的致病潜力在多微生物性尿路感染期间会被其他尿路病原体增强。
Infect Immun. 2017 Jan 26;85(2). doi: 10.1128/IAI.00808-16. Print 2017 Feb.
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Increased incidence of urolithiasis and bacteremia during Proteus mirabilis and Providencia stuartii coinfection due to synergistic induction of urease activity.由于协同诱导脲酶活性，奇异变形杆菌和斯氏普罗维登斯菌合并感染导致尿石症和菌血症发病率增加。
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Molecular Koch's postulates applied to bacterial pathogenicity--a personal recollection 15 years later.应用于细菌致病性的分子科赫法则——15年后的个人回忆
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Molecular Koch's postulates applied to microbial pathogenicity.应用于微生物致病性的分子科赫法则。
Rev Infect Dis. 1988 Jul-Aug;10 Suppl 2:S274-6. doi: 10.1093/cid/10.supplement_2.s274.