Robertson R J, Gilcher R, Metz K F, Caspersen C J, Allison T G, Abbott R A, Skrinar G S, Krause J R, Nixon P A
Human Energy Research Laboratory, School of Medicine, University of Pittsburgh, Pennsylvania 15261.
J Appl Physiol (1985). 1988 Apr;64(4):1644-9. doi: 10.1152/jappl.1988.64.4.1644.
The effect of simulated altitude erythrocythemia on hemoglobin flow rate and maximal O2 uptake (VO2max) was determined for nine women sea-level residents. Test conditions included normoxia and normobaric hypoxia (16% O2-84% N2). Cycle tests were performed under normoxia (T1-N) and hypoxia (T1-H) at prereinfusion control and under hypoxia 48 h after a placebo infusion (T2-H) and 48 h after autologous infusion of 334 ml of erythrocytes (T3-H). Hematocrit (38.1-44.9%) and hemoglobin concentration (12.7-14.7 g.dl-1) increased from control to postreinfusion. At peak exercise, VO2max decreased from T1-N (2.40 l.min-1) to T1-H (2.15 l.min-1) then increased at T3-H (2.37 l.min-1). Maximal arterial-mixed venous O2 difference decreased from T1-N to T1-H and increased at T3-H. Cardiac output (Q), stroke volume, heart rate, and total peripheral resistance during maximal exercise were unchanged from T1-N through T3-H. Hemoglobin flow rate (Hb flow) at maximum did not change from T1-N to T1-H but increased at T3-H. When compared with submaximal values for T1-N, VO2 was unchanged at T1-H and T3-H; Q increased at T1-H and decreased at T3-H; arterial-mixed venous O2 difference decreased at T1-H and increased at T3-H; Hb flow did not change at T1-N but increased at T3-H. For young women, simulated altitude erythrocythemia increased peak Hb flow and decreased physiological altitude (227.8 m) but did not affect maximum cardiac output (Qmax).
测定了9名海平面居民模拟高原红细胞增多症对血红蛋白流速和最大摄氧量（VO2max）的影响。测试条件包括常氧和常压低氧（16% O2 - 84% N2）。在常氧（T1 - N）和低氧（T1 - H）条件下，于预输注对照时进行自行车测试，并在安慰剂输注后48小时（T2 - H）和自体输注334毫升红细胞后48小时（T3 - H）的低氧条件下进行测试。血细胞比容（38.1 - 44.9%）和血红蛋白浓度（12.7 - 14.7 g·dl-1）从对照到输注后均升高。在运动峰值时，VO2max从T1 - N（2.40 l·min-1）降至T1 - H（2.15 l·min-1），然后在T
