Buick F J, Gledhill N, Froese A B, Spriet L, Meyers E C
J Appl Physiol Respir Environ Exerc Physiol. 1980 Apr;48(4):636-42. doi: 10.1152/jappl.1980.48.4.636.
The aerobic work capacity of 11 highly trained runners was studied employing a double-blind design 1) before phlebotomy (C1), 2) following restoration of normocythemia (C2), 3) after a sham reinfusion of 50 ml of saline (sham), 4) following autologous reinfusion of approximately 900 ml of freeze-preserved blood (reinfusion), and 5) upon reestablishment of control hematologic levels after erythrocythemia (C3). There were no hematologic differences among C1, C2, sham, and C3, but following reinfusion, hemoglobin was significantly elevated (15.7-16.7 g . 100 ml-1). Maximum O2 consumption (VO2max) and running time to exhaustion were significantly increased 24 h postreinfusion (5.11-5.37 l . min-1 and 7.20-9.65 min, respectively) and 7 days postreinfusion. When sham preceded reinfusion, VO2 max and time to exhaustion were the same as control. However, 16 wk postreinfusion, despite the return to normal hematologic values, VO2max remained significantly above control levels at sham and C3. These findings indicate that there is a distinct increase in VO2max following induced erythrocythemia and suggest that oxygen transport limits maximal aerobic capacity.
采用双盲设计，对11名训练有素的跑步运动员的有氧工作能力进行了研究：1）在静脉放血前（C1）；2）在恢复正常红细胞压积后（C2）；3）在假输注50毫升生理盐水后（假输注）；4）在自体输注约900毫升冷冻保存的血液后（再输注）；5）在红细胞增多症后恢复对照血液学水平时（C3）。C1、C2、假输注和C3之间在血液学方面没有差异，但在再输注后，血红蛋白显著升高（15.7 - 16.7克·100毫升⁻¹）。再输注后24小时（分别为5.11 - 5.37升·分钟⁻¹和7.20 - 9.65分钟）以及再输注后7天，最大摄氧量（VO₂max）和力竭跑步时间显著增加。当假输注先于再输注时，VO₂max和力竭时间与对照相同。然而，再输注后16周，尽管血液学值恢复正常，但VO₂max仍显著高于假输注和C3时的对照水平。这些发现表明，诱导性红细胞增多症后VO₂max有明显增加，并提示氧运输限制了最大有氧能力。
