Department of Medical Genetics, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Department of Internal Medicine and Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands.
Nat Rev Rheumatol. 2020 Feb;16(2):75-86. doi: 10.1038/s41584-019-0334-3. Epub 2019 Dec 10.
Asymptomatic hyperuricaemia affects ~20% of the general population in the USA, with variable rates in other countries. Historically, asymptomatic hyperuricaemia was considered a benign laboratory finding with little clinical importance in the absence of gout or kidney stones. Yet, increasing evidence suggests that asymptomatic hyperuricaemia can predict the development of hypertension, obesity, diabetes mellitus and chronic kidney disease and might contribute to disease by stimulating inflammation. Although urate has been classically viewed as an antioxidant with beneficial effects, new data suggest that both crystalline and soluble urate activate various pro-inflammatory pathways. This Review summarizes what is known about the role of urate in the inflammatory response. Further research is needed to define the role of asymptomatic hyperuricaemia in these pro-inflammatory pathways.
在美国，约 20%的普通人群存在无症状高尿酸血症，其他国家的发病率则有所不同。在历史上，无症状高尿酸血症被认为是一种良性的实验室发现，在没有痛风或肾结石的情况下，其临床意义不大。然而，越来越多的证据表明，无症状高尿酸血症可预测高血压、肥胖症、糖尿病和慢性肾脏病的发生，并且可能通过刺激炎症而导致疾病。虽然尿酸一直被认为是一种具有有益作用的抗氧化剂，但新数据表明，结晶尿酸和可溶性尿酸均可激活多种促炎途径。本综述总结了尿酸在炎症反应中的作用。需要进一步的研究来确定无症状高尿酸血症在这些促炎途径中的作用。
