Ran Yu, Yi Qiang, Li Cong
Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Diabetes Metab Syndr Obes. 2021 Mar 25;14:1419-1424. doi: 10.2147/DMSO.S299558. eCollection 2021.
To explore the value of anti-Mullerian hormone (AMH) in patients with polycystic ovary syndrome (PCOS) with different phenotypes and ages, and to identify the relationship between hyperandrogenism (HA) and polycystic ovary morphology (PCOM), in a Chinese cohort.
A total of 2262 women (1631 with PCOS and 631 controls) were enrolled. The serum AMH and total testosterone (TT) were analyzed, the AMH levels of each subgroup were compared, and the value of each phenotype and age group of patients with PCOS was evaluated.
The level of AMH in women with PCOS (mean±SD, 8.63±4.73 ng/mL) was higher than that in controls (5.57±3.31 ng/mL) (<0.01). The level of AMH in the PCOM subgroup (11.19±6.4 ng/mL) was significantly higher than that in the HA subgroup (8.58±4.74 ng/mL) (<0.01), and both were higher than that in controls (<0.01). AMH was higher in PCOS patients than in controls, but the same values were found in subgroups of PCOS patients under 30 years old.
AMH changed in different subgroups of PCOS, which was the possible reason why AMH was not a diagnostic indicator. However, AMH could help to differentiate between clinical subgroups, as it was strongly related with PCOM but not with HA. AMH changed substantially with age, but was stable in PCOS patients under 30 years old.
在中国人群中，探讨抗苗勒管激素（AMH）在不同表型和年龄的多囊卵巢综合征（PCOS）患者中的价值，并明确高雄激素血症（HA）与多囊卵巢形态（PCOM）之间的关系。
共纳入2262名女性（1631例PCOS患者和631例对照）。分析血清AMH和总睾酮（TT）水平，比较各亚组的AMH水平，并评估PCOS患者各表型和年龄组的价值。
PCOS女性的AMH水平（均值±标准差，8.63±4.73 ng/mL）高于对照组（5.57±3.31 ng/mL）（<0.01）。PCOM亚组的AMH水平（11.19±6.4 ng/mL）显著高于HA亚组（8.58±4.74 ng/mL）（<0.01），且两者均高于对照组（<0.01）。PCOS患者的AMH高于对照组，但30岁以下PCOS患者亚组的AMH值相同。
PCOS不同亚组中AMH有所变化，这可能是AMH不作为诊断指标的原因。然而，AMH有助于区分临床亚组，因为它与PCOM密切相关而与HA无关。AMH随年龄有显著变化，但在30岁以下的PCOS患者中较为稳定。
