Department of Prosthodontics, Islamabad Medical and Dental College, 45400, Pakistan.
Department of Oral Biology, Institute of Dentistry, CMH Lahore Medical & Dental College, National University of Medical Sciences, 54810, Pakistan.
Biomed Res Int. 2021 Mar 13;2021:6685991. doi: 10.1155/2021/6685991. eCollection 2021.
The possibility of platelet-rich plasma (PRP) on the improvement of bone and adjacent tissue recovery has previously been validated. However, there is insufficient data supporting the use of platelet-rich plasma to improve the healing of bone and adjacent tissues around an implant in the oral cavity. The purpose of this randomized controlled trial was to observe the effect of platelet-rich plasma (PRP) concentrate on marginal bone loss and bone density around immediate implant placement using Cone Beam Computerized Tomography (CBCT). This clinical study was conducted over a period of six months on 12 subjects, who were equally categorized into two groups. Group I was the control, whereas the subjects in Group II received PRP therapy at the surgical site. All subjects were given a standard treatment with a single implant system (DIO UFII hybrid sandblasted acid-etched implants). Inserted implants were analyzed through CBCT, and records were registered at baseline, at the 12 week before functional loading and the 26 week after functional loading. The bone loss was calculated at the proximal (mesial and distal) side of the implant and bone density at baseline, 12 week, and 26 week after implant placement. SPSS version 23.0 was used for statistical analysis of data. The changes in bone levels were measured and compared between the two groups using the Mann-Whitney test, with no significant difference. Bone density was analyzed by an independent sample -test, value ≤ 0.05 was considered statistically significant. Again, no significant difference in bone density was observed between both groups at all three instances. Therefore, it can be concluded that local injection of PRP after immediate implant placement did not show any decrease in marginal bone loss or improvement in bone density. This trial is registered with NCT04650763.
富血小板血浆（PRP）在改善骨和相邻组织恢复方面的可能性先前已经得到验证。然而，目前还没有足够的数据支持使用富血小板血浆来改善口腔内植入物周围骨和相邻组织的愈合。本随机对照试验的目的是使用锥形束计算机断层扫描（CBCT）观察富血小板血浆（PRP）浓缩物对即刻种植体放置后边缘骨丢失和骨密度的影响。这项临床研究在 12 名受试者中进行了六个月，他们被平均分为两组。第 I 组为对照组，而第 II 组在手术部位接受 PRP 治疗。所有受试者均采用单一种植体系统（DIO UFII 混合喷砂酸蚀种植体）进行标准治疗。通过 CBCT 分析植入的种植体，并在基线、功能加载前 12 周和功能加载后 26 周记录。在种植体的近侧（近中和远中）侧计算骨丢失，并在基线、12 周和 26 周后测量和记录骨密度。使用 SPSS 版本 23.0 对数据进行统计分析。使用 Mann-Whitney 检验比较两组之间的骨水平变化，无显著差异。通过独立样本 t 检验分析骨密度， 值≤0.05 被认为具有统计学意义。同样，在所有三个时间点，两组之间的骨密度均无显著差异。因此，可以得出结论，即刻种植体放置后局部注射 PRP 不会导致边缘骨丢失减少或骨密度改善。本试验已在 NCT04650763 注册。
