Western Health Science Academy, Pokhara, Kaski, Nepal.
Pharmaceutical Sciences Program, School of Health and Allied Sciences, Pokhara University, Kaski, Nepal.
Biomed Res Int. 2021 Mar 15;2021:6699028. doi: 10.1155/2021/6699028. eCollection 2021.
Depression is a major global health problem with a relatively high lifetime prevalence and significant disability. Antidepressants are the most effective medications used for the treatment of depression. Hence, this study is aimed at summarizing the studies on antidepressant use among patients diagnosed with depression.
PubMed, Embase, Web of Science, Scopus, and Google Scholar were searched for literature (2000-2019) using keywords such as depression, drug utilization, antidepressants, prescription, serotonin reuptake inhibitor, serotonin and norepinephrine reuptake inhibitor, tricyclic antidepressants, and atypical antidepressants.
Antidepressant users were mostly females, married people, housewives, lower-income people, employees, and highly educated people, as they were found to be more prone to develop depression than their counterparts. Selective serotonin reuptake inhibitors (SSRIs), such as sertraline, were most commonly prescribed among depressive patients.
Our study suggested that out of five major antidepressant drugs available for the treatment of depression, selective serotonin reuptake inhibitors are preferred over others because of their better side effects and tolerability profile.
抑郁症是一个全球性的主要健康问题，具有相对较高的终生患病率和显著的残疾。抗抑郁药是治疗抑郁症最有效的药物。因此，本研究旨在总结抑郁症患者使用抗抑郁药的研究。
使用关键词如抑郁症、药物利用、抗抑郁药、处方、选择性 5-羟色胺再摄取抑制剂、5-羟色胺和去甲肾上腺素再摄取抑制剂、三环抗抑郁药和非典型抗抑郁药，在 PubMed、Embase、Web of Science、Scopus 和 Google Scholar 上搜索文献（2000-2019 年）。
抗抑郁药使用者主要是女性、已婚人士、家庭主妇、低收入人群、雇员和受教育程度较高的人群，因为他们比同龄人更容易患上抑郁症。选择性 5-羟色胺再摄取抑制剂（SSRIs），如舍曲林，是最常用于治疗抑郁症患者的药物。
我们的研究表明，在治疗抑郁症的五种主要抗抑郁药中，选择性 5-羟色胺再摄取抑制剂因其更好的副作用和耐受性而优于其他药物。
