Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Rev Neurosci. 2021 Apr 1;32(8):833-849. doi: 10.1515/revneuro-2020-0144. Print 2021 Dec 20.
Extracellular vesicles (EVs) are a heterogeneous group of cell-derived membranous vesicles secreted by various cells in the extracellular space. Accumulating evidence shows that EVs regulate cell-to-cell communication and signaling in the pathological processes of various diseases by carrying proteins, lipids, and nucleic acids to recipient cells. Glia-derived EVs act as a double-edged sword in the pathogenesis of central nervous system (CNS) diseases. They may be vectors for the spread of diseases or act as effective clearance systems to protect tissues. In this review, we summarize recent studies on glia-derived EVs with a focus on their relationships with CNS diseases.
细胞外囊泡（EVs）是一类由各种细胞在细胞外空间分泌的异质性细胞衍生的膜性囊泡。越来越多的证据表明，EVs 通过将蛋白质、脂质和核酸携带到受体细胞中，调节各种疾病病理过程中的细胞间通讯和信号转导。胶质细胞衍生的 EVs 在中枢神经系统（CNS）疾病的发病机制中起着双刃剑的作用。它们可能是疾病传播的载体，也可能是保护组织的有效清除系统。在这篇综述中，我们总结了最近关于胶质细胞衍生的 EVs 的研究，重点介绍了它们与 CNS 疾病的关系。
