Department of Materials Engineering, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Brazilian Health Regulatory Agency, Porto Alegre, RS, Brazil.
J Mater Sci Mater Med. 2021 Apr 1;32(4):38. doi: 10.1007/s10856-021-06507-9.
The use of drug delivery systems is a good technique to leave the right quantity of medicine in the patient's body in a suitable dose, because the drug application is delivered directly to the affected region. The current techniques such as HPLC and UV-Vis for the drug delivery calculation has some disadvantages, as the accuracy and the loss of the sample after characterization. With the aim of reducing the amount of material used during the characterization and have a non-destructive test with instantaneous results, the present paper shows the possibility of using electrochemical impedance spectroscopy (EIS) to have a drug delivery measurement during the release phenomena for a calcium phosphate cement (CFC) delivery system with gentamicin sulfate (GS) and lidocaine hydrochloride (LH), at a ratio of 1% and 2%, respectively. The equivalent circuit and the chemical mechanism involved during the measurements have been proposed as a tool to determine the drug delivery profile. The method has been compared with the UV-Vis technique. XRD was realized to verify conditions, before and after release. It was possible to verify the potential for using EIS as an instant technique to quantify drug delivery.
药物传递系统的使用是一种将适量的药物以合适的剂量输送到患者体内的好方法，因为药物应用是直接输送到受影响的区域。目前用于药物传递计算的技术，如 HPLC 和 UV-Vis，存在一些缺点，如准确性和样品在特征描述后的损失。为了减少在特征描述过程中使用的材料量，并进行具有瞬时结果的非破坏性测试，本文展示了使用电化学阻抗谱（EIS）在释放现象期间对具有硫酸庆大霉素（GS）和盐酸利多卡因（LH）的钙磷酸盐水泥（CFC）输送系统进行药物输送测量的可能性，分别为 1%和 2%。已经提出了等效电路和测量过程中涉及的化学机制作为确定药物输送曲线的工具。该方法已与 UV-Vis 技术进行了比较。进行了 XRD 以验证释放前后的条件。可以验证使用 EIS 作为即时技术定量药物输送的潜力。
