Institute of Radiology, Department of Medicine (DIMED), University Hospital of Padova, Padova, Italy.
Clinica Chirurgica I, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University Hospital of Padova, Via Nicolò Giustiniani 2, 35128, Padova, Italy.
Tech Coloproctol. 2021 May;25(5):569-577. doi: 10.1007/s10151-021-02440-9. Epub 2021 Apr 1.
The aim of our study was to investigate the correlation among T2-weighted (T2w) images, apparent diffusion coefficient (ADC) maps, F-fluorodeoxyglucose (F-FDG) positron emission tomography (PET) images, histogram analysis and the pathological response in locally advanced rectal cancer (LARC) after preoperative chemoradiotherapy (pCRT).
Patients with LARC were prospectively enrolled between February 2015 and August 2018 and underwent PET/magnetic resonance imaging (MRI). MRI included T2w and diffusion-weighted imaging (DWI)-sequences. ADC maps and PET images were matched to the T2w images. Voxel-based standardized uptake values (SUVs,) ADC and T2w-signal-intensity values were collected from the volumes of interest (VOIs) and mean, skewness and kurtosis were calculated. Spearman's correlation coefficient was applied to evaluate the correlation among the variables and tumor regression grade (TRG), T stage, N stage and fibrosis.
Twenty-two patients with biopsy-proven LARC in the low or mid rectum were enrolled [17 males, mean age was 69 years (range 49-85 years)]. Seven patients experienced complete regression (TRG1). A significant positive correlation was found between SUV mean values (ρ = 0.480; p = 0.037) and TRG. No other significant correlations were found.
Histogram analysis of SUV values is a predictor of TRG in LARC.
我们研究的目的是探讨局部进展期直肠癌（LARC）患者术前放化疗（pCRT）后 T2 加权（T2w）图像、表观扩散系数（ADC）图、氟代脱氧葡萄糖（F-FDG）正电子发射断层扫描（PET）图像、直方图分析与病理反应之间的相关性。
2015 年 2 月至 2018 年 8 月，前瞻性地纳入了 LARC 患者，并进行了 PET/磁共振成像（MRI）检查。MRI 包括 T2w 和弥散加权成像（DWI）序列。ADC 图和 PET 图像与 T2w 图像匹配。从感兴趣区（VOI）中采集了基于体素的标准化摄取值（SUV）、ADC 和 T2w 信号强度值，并计算了平均值、偏度和峰度。采用 Spearman 相关系数评估了变量与肿瘤退缩分级（TRG）、T 分期、N 分期和纤维化之间的相关性。
共纳入 22 例经活检证实的低位或中位直肠 LARC 患者[17 例男性，平均年龄 69 岁（范围 49-85 岁）]。7 例患者完全退缩（TRG1）。SUV 平均值与 TRG 之间存在显著正相关（ρ=0.480；p=0.037）。未发现其他显著相关性。
SUV 值的直方图分析是预测 LARC 中 TRG 的指标。
