眼底照相和视网膜电流图在鸟枪弹样脉络膜视网膜病变中的相关性。

Electroretinogram and Visual Field Correlation in Birdshot Chorioretinopathy.

机构信息

USC Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA.

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.

出版信息

Asia Pac J Ophthalmol (Phila). 2021 Feb 3;10(2):208-211. doi: 10.1097/APO.0000000000000374.

DOI:10.1097/APO.0000000000000374

PMID:33793442

Abstract

PURPOSE

The aim of this study was to assess possible correlation between the visual field and electroretinogram (ERG) parameters in birdshot chorioretinopathy (BCR).

DESIGN

Retrospective cross-sectional study.

METHODS

This single-center study included 21 eyes of 11 patients with BCR with prior ERG and Goldmann kinetic perimetry. Generalized estimating equation was used for statistical analysis, and isopters V4e and I4e were modeled as separate outcomes with each parameter of ERG as the main independent variable. The main outcome measure was presence or absence of correlation between the Goldmann isopters and ERG parameters including the amplitudes and implicit times of dark adapted (DA) and light adapted (LA) a-waves and b-waves (DA 0.01, DA 3.0, DA 10.0, and LA 3.0) and LA 30 Hz.

RESULTS

There was a strong positive correlation between the size of isopter V4e and all the scotopic and photopic standard ERG amplitudes [P < 0.0001 for all, except LA 3.0 a-wave (P = 0.0019) and LA 30 Hz (P = 0.0026)]. For the implicit times, only DA 3.0 a-wave (P = 0.007) and LA 30 Hz (P < 0.0001) showed significant negative correlations. There were no correlations between the size of isopter I4e and any ERG amplitudes; however, 3 implicit times showed some negative correlation: DA 3.0 a-wave (P < 0.0001), DA 10.0 b-wave (P = 0.0251), and LA 3.0 b-wave (P < 0.0001).

CONCLUSIONS

In this study, the largest isopter of Glodmann visual field showed a strong positive correlation with all standard ERG amplitudes in BCR. This novel finding underscores the role of ERG as an objective visual function test in monitoring the disease activity.

摘要

目的

本研究旨在评估鸟枪弹样脉络膜视网膜病变（BCR）患者的视野与视网膜电图（ERG）参数之间的可能相关性。

设计

回顾性横断面研究。

方法

本单中心研究纳入了 11 例 BCR 患者的 21 只眼，这些患者均有 ERG 和 Goldmann 动态视野检查的病史。采用广义估计方程进行统计学分析，将 V4e 等视线和 I4e 等视线分别建模为两个独立变量，每个 ERG 参数作为主要自变量。主要观察指标为 Goldmann 等视线与 ERG 参数（包括暗适应（DA）和明适应（LA）a 波和 b 波的振幅和潜伏期，即 DA 0.01、DA 3.0、DA 10.0 和 LA 3.0，以及 LA 30Hz）之间是否存在相关性。

结果

V4e 等视线的大小与所有暗视和明视标准 ERG 振幅均呈强烈正相关（所有 P 值均＜0.0001，除 LA 3.0 a 波（P=0.0019）和 LA 30Hz（P=0.0026）外）。对于潜伏期，仅 DA 3.0 a 波（P=0.007）和 LA 30Hz（P＜0.0001）显示出显著的负相关。I4e 等视线的大小与任何 ERG 振幅均无相关性；然而，有 3 个潜伏期显示出一定的负相关：DA 3.0 a 波（P＜0.0001）、DA 10.0 b 波（P=0.0251）和 LA 3.0 b 波（P＜0.0001）。