Save Sight Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
The Speciality of Ophthalmology Faculty of Medicine and Health University of Sydney, Camperdown, New South Wales, Australia.
Transl Vis Sci Technol. 2022 May 2;11(5):23. doi: 10.1167/tvst.11.5.23.
The flicker electroretinogram (ERG) is a sensitive indicator of retinal dysfunction in birdshot chorioretinopathy (BCR). We explored recordings from a handheld device in BCR, comparing these with conventional recordings in the same patients and with handheld ERGs from healthy individuals.
Non-mydriatic flicker ERGs, using the handheld RETeval system (LKC Technologies), were recorded with skin electrodes at two centers. At one center (group 1), the stimuli (85 Td·s, 850 Td background) delivered retinal illuminance equivalent to international standards; at the other center (group 2), a different protocol was used (32 Td·s, no background). Patients also underwent international standard flicker ERG recordings with conventional electrodes following mydriasis. Portable ERGs from patients were also compared with those from healthy individuals.
Thirty-two patients with BCR (mean age ± SD, 56.4 ± 11.3 years) underwent recordings. Portable and standard ERG parameters correlated strongly (r > 0.75, P < 0.01) in both groups. Limits of agreement for peak times were tighter in group 1 (n = 21; -4.3 to +2.0 ms [right eyes], -3.9 to 1.5 ms [left eyes]) than in group 2 (n = 11; -3.4 to +6.9 ms [right eyes], -4.8 to +9.0 ms [left eyes]). Compared with healthy controls (n = 66 and n = 90 for groups 1 and 2, respectively), patients with BCR showed smaller mean amplitudes and longer peak times.
Portable ERGs correlated strongly with conventional recordings, suggesting potential in rapid assessment of cone system function in office settings.
Flicker ERGs, known to be useful in BCR, can be obtained rapidly with a portable device with skin electrodes and natural pupils.
闪烁视网膜电图（ERG）是鸟枪弹样脉络膜视网膜病变（BCR）视网膜功能障碍的敏感指标。我们探索了手持式设备在 BCR 中的记录，将这些记录与同一患者的常规记录以及健康个体的手持式 ERG 进行了比较。
使用 LKC 技术的非散瞳闪烁 ERG，在两个中心使用皮肤电极进行记录。在一个中心（第 1 组），刺激（85 Td·s，850 Td 背景）提供相当于国际标准的视网膜照度；在另一个中心（第 2 组），使用不同的方案（32 Td·s，无背景）。患者还接受了散瞳后国际标准闪烁 ERG 记录。还将患者的便携式 ERG 与健康个体的 ERG 进行了比较。
32 例 BCR 患者（平均年龄±标准差，56.4±11.3 岁）接受了记录。两组的便携式和标准 ERG 参数相关性均很强（r>0.75，P<0.01）。第 1 组（n=21；右眼为-4.3 至+2.0ms，左眼为-3.9 至 1.5ms）的峰时限值比第 2 组（n=11；右眼为-3.4 至+6.9ms，左眼为-4.8 至+9.0ms）更紧。与健康对照组（第 1 组和第 2 组分别为 n=66 和 n=90）相比，BCR 患者的平均振幅较小，峰时较长。
便携式 ERG 与常规记录相关性很强，表明在办公室环境中快速评估视锥系统功能具有潜力。
王超
