健康人类肠道微生物群在生命最初5年的发育轨迹。

Developmental trajectory of the healthy human gut microbiota during the first 5 years of life.

作者信息

Roswall Josefine, Olsson Lisa M, Kovatcheva-Datchary Petia, Nilsson Staffan, Tremaroli Valentina, Simon Marie-Christine, Kiilerich Pia, Akrami Rozita, Krämer Manuela, Uhlén Mathias, Gummesson Anders, Kristiansen Karsten, Dahlgren Jovanna, Bäckhed Fredrik

机构信息

Hallands Hospital Halmstad, Department of Pediatrics, Halmstad, Sweden; Gothenburg Pediatric Growth Research Center, Department of Pediatrics, Institute of Clinical Sciences, University of Gothenburg, Gothenburg, Sweden.

The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

出版信息

Cell Host Microbe. 2021 May 12;29(5):765-776.e3. doi: 10.1016/j.chom.2021.02.021. Epub 2021 Mar 31.

DOI:10.1016/j.chom.2021.02.021

PMID:33794185

Abstract

The gut is inhabited by a densely populated ecosystem, the gut microbiota, that is established at birth. However, the succession by which different bacteria are incorporated into the gut microbiota is still relatively unknown. Here, we analyze the microbiota from 471 Swedish children followed from birth to 5 years of age, collecting samples after 4 and 12 months and at 3 and 5 years of age as well as from their mothers at birth using 16S rRNA gene profiling. We also compare their microbiota to an adult Swedish population. Genera follow 4 different colonization patterns during establishment where Methanobrevibacter and Christensenellaceae colonize late and do not reached adult levels at 5 years. These late colonizers correlate with increased alpha diversity in both children and adults. By following the children through age-specific community types, we observe that children have individual dynamics in the gut microbiota development trajectory.

摘要

肠道中栖息着一个人口密集的生态系统——肠道微生物群，它在出生时就已建立。然而，不同细菌融入肠道微生物群的 succession 仍然相对不为人知。在这里，我们分析了 471 名瑞典儿童从出生到 5 岁的微生物群，在 4 个月和 12 个月以及 3 岁和 5 岁时收集样本，并在出生时收集他们母亲的样本，使用 16S rRNA 基因谱分析。我们还将他们的微生物群与瑞典成年人群体进行比较。在建立过程中，属遵循 4 种不同的定殖模式，其中 Methanobrevibacter 和 Christensenellaceae 定殖较晚，在 5 岁时未达到成人水平。这些晚期定殖者与儿童和成人中增加的α多样性相关。通过跟踪儿童特定年龄的群落类型，我们观察到儿童在肠道微生物群发育轨迹上具有个体动态。