妊娠与多发性硬化症
Pregnancy and multiple sclerosis.
作者信息
Frith J A, McLeod J G
机构信息
Department of Medicine, University of Sydney, N.S.W., Australia.
出版信息
J Neurol Neurosurg Psychiatry. 1988 Apr;51(4):495-8. doi: 10.1136/jnnp.51.4.495.
Abstract
The effect of pregnancy on the relapse rate of multiple sclerosis has been investigated. Obstetric and relapse histories of 52 women with clinically definite multiple sclerosis were obtained; there were 101 pregnancies of which 85 were at risk of a multiple sclerosis relapse. By comparing the number of relapses in the pregnancy period (9 months of pregnancy and 6 months immediately post partum) with the number in non-pregnancy periods for the same women, no increased risk of relapse during the pregnancy period was demonstrated. However, of the relapses that did occur during the pregnancy period, there was a significant reduction in the number of relapses in the first and second trimesters.
摘要
已对妊娠对多发性硬化症复发率的影响进行了研究。获取了52例临床确诊为多发性硬化症女性的产科和复发史；共有101次妊娠，其中85次有多发性硬化症复发风险。通过比较同一女性妊娠期（妊娠9个月和产后即刻6个月）的复发次数与非妊娠期的复发次数，未发现妊娠期复发风险增加。然而，在妊娠期确实发生的复发中，孕早期和孕中期的复发次数显著减少。
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