Worthington J, Jones R, Crawford M, Forti A
CMH Multiple Sclerosis Unit, Central Middlesex Hospital, London, UK.
J Neurol. 1994 Feb;241(4):228-33. doi: 10.1007/BF00863773.
A prospective study of the level of disability, severity and distribution of relapses in 15 women with multiple sclerosis prior to, during and up to 3 years following pregnancy was undertaken. The pregnant group was compared with 22 nulliparous women attending the same clinic and matched for age and severity and duration of disease. In the pregnant group, relapses were more frequent and severe than expected values during the first 6 months post partum, but were below expected values 6-24 months post partum. Over the total study period, therefore, there were no significant differences in relapse number, Expanded Disability Status Score or functional scores between the two groups. Babies born during the study showed normal distributions of weight and head circumference.
对15名患有多发性硬化症的女性在怀孕前、怀孕期间及产后长达3年的残疾程度、复发的严重程度和分布情况进行了一项前瞻性研究。将怀孕组与在同一诊所就诊、年龄、疾病严重程度和病程相匹配的22名未生育女性进行比较。在怀孕组中，产后前6个月复发比预期更频繁、更严重，但产后6 - 24个月低于预期值。因此，在整个研究期间，两组之间的复发次数、扩展残疾状态评分或功能评分没有显著差异。研究期间出生的婴儿体重和头围分布正常。
