Division of Pediatric Endocrinology, Department of Pediatrics, School of Medicine, Marmara University, Istanbul, Turkey.
Horm Res Paediatr. 2020;93(9-10):497-509. doi: 10.1159/000515347. Epub 2021 Apr 1.
Craniopharyngioma (CP), despite being a malformational tumor of low histological grade, causes considerable morbidity and mortality mostly due to hypothalamo-pituitary dysfunction that is created by tumor itself or its treatment.
Fluid-electrolyte disturbances which range from dehydration to fluid overload and from hypernatremia to hyponatremia are frequently encountered during the acute postoperative period and should be carefully managed to avoid permanent neurological sequelae. Hypopituitarism, increased cardiovascular risk, hypothalamic damage, hypothalamic obesity, visual and neurological deficits, and impaired bone health and cognitive function are the morbidities affecting the well-being of these patients in the long term. Key Messages: Timely and optimal treatment of early postoperative and long-term complications of CP is crucial for preserving quality of life of these patients.
颅咽管瘤（CP）尽管是一种组织学分级较低的先天肿瘤，但由于肿瘤本身或其治疗引起的下丘脑-垂体功能障碍，导致相当高的发病率和死亡率。
在急性术后期间，经常会出现从脱水到水过多，从高钠血症到低钠血症等各种液体电解质紊乱，应谨慎处理以避免永久性神经后遗症。垂体功能减退、心血管风险增加、下丘脑损伤、下丘脑性肥胖、视力和神经功能缺损以及骨健康和认知功能受损是影响这些患者长期生活质量的并发症。
及时和优化治疗 CP 的术后早期和长期并发症对于维持这些患者的生活质量至关重要。
