药物依从性受系统性红斑狼疮患者韧性的影响。

Medication adherence is influenced by resilience in patients with systemic lupus erythematosus.

机构信息

Systemic Autoimmune Diseases Research Unit, High-Specialty Medical Unit-CIBIOR, Mexican Social Security Institute, Puebla, México.

Department of Rheumatology and Immunology, Medicine School, Meritorious Autonomous University of Puebla, Puebla, Mexico.

出版信息

Lupus. 2021 Jun;30(7):1051-1057. doi: 10.1177/09612033211004722. Epub 2021 Apr 1.

DOI:10.1177/09612033211004722

PMID:33794703

Abstract

OBJECTIVE

Evidence on the relationship between resilience and medication adherence in systemic lupus erythematosus (SLE) patients is lacking. We aimed to examine the impact of resilience on medication adherence in SLE patients.

METHOD

In a cross-sectional analysis SLE outpatients were assessed for resilience (Connor-Davison Resilience Scale, CD-RISC), depressive symptoms (CES-D) and medication adherence (Compliance Questionnaire for Rheumatology [CQR]). The disease activity index (mexSLEDAI) and damage (SLICC Damage Index) were administered. Factors independently associated with adherence were identified using multivariate logistic regression.

RESULTS

Of the 157 patients, 152 (96.8%) were female with a median age of 45.9 (IQR: 39.0-55.5) years and disease duration of 14 (IQR: 10.0-19.0) years. Medication adherence (CQR ≥80%) and depressive symptoms were found in 74.5% and 43.9% of patients, respectively. Adherent patients had a lower CES-D score and a higher CD-RISC score. In the multivariate analysis adjusting for demographic and clinical confounders, resilience and older age protected against non-adherence (OR 0.96, [95% CI 0.94-0.99] and OR 0.96 [95% CI 0.93-0.98], respectively).

CONCLUSION

In SLE patients, resilience and older age, which possibly associated with better medication adherence, may protect against non-adherence.

摘要

目的

关于红斑狼疮患者（SLE）的韧性和药物依从性之间关系的证据尚缺乏。我们旨在探讨韧性对 SLE 患者药物依从性的影响。

方法

在一项横断面分析中，对 SLE 门诊患者进行了韧性（Connor-Davison 韧性量表，CD-RISC）、抑郁症状（CES-D）和药物依从性（风湿病依从性问卷[CQR]）评估。评估疾病活动指数（mexSLEDAI）和损伤（SLICC 损伤指数）。使用多元逻辑回归确定与依从性独立相关的因素。

结果

在 157 例患者中，152 例（96.8%）为女性，中位年龄为 45.9（IQR：39.0-55.5）岁，病程为 14（IQR：10.0-19.0）年。分别有 74.5%和 43.9%的患者药物依从性（CQR≥80%）和抑郁症状。依从性患者的 CES-D 评分较低，CD-RISC 评分较高。在调整人口统计学和临床混杂因素的多变量分析中，韧性和年龄较大可预防不依从（OR 0.96，[95%CI 0.94-0.99]和 OR 0.96 [95%CI 0.93-0.98]）。