Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P.O. Box 14155-6117, Tehran, Iran.
Department of Clinical Nutrition and Dietetics, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nutr J. 2021 Apr 1;20(1):31. doi: 10.1186/s12937-021-00689-2.
BACKGROUND & AIM: No study is available that explores the association of dietary phytochemical index (DPI) with glioma. The objective of the current study was to assess this association in Iranian adults.
This hospital-based case-control study included 128 newly-diagnosed cases of glioma and 256 age- and sex-matched controls. Data collection on dietary intakes was done using a 123-item validated food frequency questionnaire. Calculation of DPI was done as (dietary energy derived from phytochemical-rich foods (kcal)/total daily energy intake (kcal)) × 100. Logistic regression models were used to examine the association between DPI and glioma.
Individuals in the top tertile of DPI were more likely to be older and female. Before taking potential confounders into account, subjects in the top tertile of DPI tended to have a 40% reduced chance of glioma than those in the bottom tertile (OR: 0.60; 95% CI: 0.35-1.02, P = 0.06). After controlling for age, sex, energy intake, several demographic variables and dietary intakes, the association between DPI and glioma became strengthened (OR: 0.43; 95% CI: 0.19-0.97, P = 0.04).
High intakes of phytochemical-rich foods were associated with a lower risk of glioma in adults. High consumption of phytochemical-rich foods might be recommended to prevent glioma. However, further studies with a prospective design are needed to confirm our findings.
目前尚无研究探讨膳食植物化学指数（DPI）与胶质瘤之间的关联。本研究旨在评估伊朗成年人中这种关联。
本项基于医院的病例对照研究纳入了 128 例新诊断的胶质瘤患者和 256 名年龄和性别匹配的对照。采用经过验证的 123 项食物频率问卷收集膳食摄入量数据。DPI 的计算方法为（富含植物化学物质的食物的膳食能量（千卡）/总每日能量摄入（千卡））×100。使用逻辑回归模型来检验 DPI 与胶质瘤之间的关联。
DPI 处于最高三分位的个体更可能年龄较大且为女性。在考虑潜在混杂因素之前，DPI 处于最高三分位的受试者患胶质瘤的几率比处于最低三分位的受试者低 40%（OR：0.60；95%CI：0.35-1.02，P=0.06）。在控制年龄、性别、能量摄入、几个人口统计学变量和膳食摄入量后，DPI 与胶质瘤之间的关联得到加强（OR：0.43；95%CI：0.19-0.97，P=0.04）。
大量摄入富含植物化学物质的食物与成年人患胶质瘤的风险降低相关。建议高消费富含植物化学物质的食物以预防胶质瘤。但是，需要进一步的前瞻性研究来证实我们的发现。
