COVID-19 诱导的 ARDS 中淀粉样蛋白形成的可能性。
Likelihood of amyloid formation in COVID-19-induced ARDS.
机构信息
Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, UP 208016, India.
Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, UP 208016, India.
出版信息
Trends Microbiol. 2021 Nov;29(11):967-969. doi: 10.1016/j.tim.2021.03.008. Epub 2021 Mar 29.
Severe coronavirus disease 2019 (COVID-19) infection leads to multifactorial acute respiratory distress syndrome (ARDS), with little therapeutic success. The pathophysiology associated with ARDS or post-ARDS is not yet well understood. We hypothesize that amyloid formation occurring due to protein homeostasis disruption can be one of the complications associated with COVID-19-induced-ARDS.
严重的 2019 年冠状病毒病（COVID-19）感染可导致多因素急性呼吸窘迫综合征（ARDS），治疗效果甚微。与 ARDS 或 ARDS 后相关的病理生理学尚未得到很好的理解。我们假设，由于蛋白质内稳态破坏而发生的淀粉样形成可能是与 COVID-19 引起的 ARDS 相关的并发症之一。
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