先前感染过 SARS-CoV-2 的个体对 BNT162b2 mRNA 疫苗的抗体反应。
Antibody responses to the BNT162b2 mRNA vaccine in individuals previously infected with SARS-CoV-2.
机构信息
Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Advanced Clinical Biosystems Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
出版信息
Nat Med. 2021 Jun;27(6):981-984. doi: 10.1038/s41591-021-01325-6. Epub 2021 Apr 1.
In a cohort of BNT162b2 (Pfizer-BioNTech) mRNA vaccine recipients (n = 1,090), we observed that spike-specific IgG antibody levels and ACE2 antibody binding inhibition responses elicited by a single vaccine dose in individuals with prior SARS-CoV-2 infection (n = 35) were similar to those seen after two doses of vaccine in individuals without prior infection (n = 228). Post-vaccine symptoms were more prominent for those with prior infection after the first dose, but symptomology was similar between groups after the second dose.
在 BNT162b2（辉瑞-生物科技）mRNA 疫苗接种者队列中（n=1090），我们观察到，在既往 SARS-CoV-2 感染的个体（n=35）中，单次接种疫苗后诱导的刺突特异性 IgG 抗体水平和 ACE2 抗体结合抑制反应与未感染个体中两次接种疫苗后观察到的相似（n=228）。在初次接种后，既往感染者的疫苗后症状更为明显，但在第二次接种后，两组的症状相似。
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