• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

蛋白质组学分析揭示氧化应激导致的肩袖损伤。

Proteomic analysis reveals rotator cuff injury caused by oxidative stress.

作者信息

Yuan Tao, Qian Hong, Yu Xin, Meng Jia, Lai Cheng-Teng, Jiang Hui, Zhao Jian-Ning, Bao Ni-Rong

机构信息

The First School of Clinical Medicine, Southern Medical University, Guangzhou, China.

Department of Orthopedics, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

出版信息

Ther Adv Chronic Dis. 2021 Mar 17;12:2040622320987057. doi: 10.1177/2040622320987057. eCollection 2021.

DOI:10.1177/2040622320987057
PMID:33796243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7975570/
Abstract

BACKGROUND AND AIMS

Rotator cuff tendinopathy is common and is related to pain and dysfunction. However, the pathological mechanism of rotator cuff injury and shoulder pain is unclear. Objective: to investigate the pathological mechanism of rotator cuff injury and shoulder pain, and screen out the marker proteins related to rotator cuff injury by proteomics.

METHODS

Subacromial synovium specimens were collected from patients undergoing shoulder arthroscopic surgery. The experimental group were patients with rotator cuff repair surgery, and the control group were patients with habitual dislocation of the shoulder joint. Pathological examination was performed, and then followed by non-labeled quantitative proteomic detection. Finally, from analysis of the biological information of the samples, specific proteins related to rotator cuff injury and shoulder pain were deduced by functional analysis of differential proteins.

RESULTS

All the patients in experimental groups were representative. A large number of adipocytes and inflammatory cells were found in the pathological sections of the experimental group; the proteomics analysis screen identified 80 proteins with significant differences, and the analysis of protein function revealed that S100A11 ( = 0.011), PLIN4 ( = 0.017), HYOU1 ( = 0.002) and CLIC1 ( = 0.007) were closely related to oxidative stress and chronic inflammation.

CONCLUSION

Rotator cuff injury is closely related to oxidative stress and chronic inflammatory response, and the results suggest that the expression of S100A11, PLIN4, HYOU1 and CLIC1 in the synovium of rotator cuff injury provides a new marker for the study of its pathological mechanism.

摘要

背景与目的

肩袖肌腱病很常见，且与疼痛和功能障碍有关。然而，肩袖损伤和肩部疼痛的病理机制尚不清楚。目的：探讨肩袖损伤和肩部疼痛的病理机制，并通过蛋白质组学筛选出与肩袖损伤相关的标志物蛋白。

方法

收集接受肩关节镜手术患者的肩峰下滑膜标本。实验组为接受肩袖修复手术的患者，对照组为肩关节习惯性脱位患者。进行病理检查，然后进行非标记定量蛋白质组学检测。最后，通过对样本的生物学信息分析，对差异蛋白进行功能分析，推导与肩袖损伤和肩部疼痛相关的特异性蛋白。

结果

实验组所有患者均具有代表性。实验组病理切片中发现大量脂肪细胞和炎性细胞；蛋白质组学分析筛选出80种有显著差异的蛋白质，蛋白质功能分析显示S100A11（=0.011）、PLIN4（=0.017）、HYOU1（=0.002）和CLIC1（=0.007）与氧化应激和慢性炎症密切相关。

结论

肩袖损伤与氧化应激和慢性炎症反应密切相关，结果表明S100A11、PLIN4、HYOU1和CLIC1在肩袖损伤滑膜中的表达为其病理机制的研究提供了新的标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/8b0783a5f54c/10.1177_2040622320987057-fig14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/b15218bb9105/10.1177_2040622320987057-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/4f7ec8ef2ced/10.1177_2040622320987057-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/1ba44386fb51/10.1177_2040622320987057-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/46ae6f94e0b8/10.1177_2040622320987057-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/d97d0175934d/10.1177_2040622320987057-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/3d30166a6cab/10.1177_2040622320987057-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/fc567b65d17b/10.1177_2040622320987057-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/7e890df807f7/10.1177_2040622320987057-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/c86f399df709/10.1177_2040622320987057-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/30556bfbcd8e/10.1177_2040622320987057-fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/911d72fbfc58/10.1177_2040622320987057-fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/a4f3617ae960/10.1177_2040622320987057-fig12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/521e0d54b61b/10.1177_2040622320987057-fig13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/8b0783a5f54c/10.1177_2040622320987057-fig14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/b15218bb9105/10.1177_2040622320987057-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/4f7ec8ef2ced/10.1177_2040622320987057-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/1ba44386fb51/10.1177_2040622320987057-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/46ae6f94e0b8/10.1177_2040622320987057-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/d97d0175934d/10.1177_2040622320987057-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/3d30166a6cab/10.1177_2040622320987057-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/fc567b65d17b/10.1177_2040622320987057-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/7e890df807f7/10.1177_2040622320987057-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/c86f399df709/10.1177_2040622320987057-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/30556bfbcd8e/10.1177_2040622320987057-fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/911d72fbfc58/10.1177_2040622320987057-fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/a4f3617ae960/10.1177_2040622320987057-fig12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/521e0d54b61b/10.1177_2040622320987057-fig13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc6/7975570/8b0783a5f54c/10.1177_2040622320987057-fig14.jpg

相似文献

1
Proteomic analysis reveals rotator cuff injury caused by oxidative stress.蛋白质组学分析揭示氧化应激导致的肩袖损伤。
Ther Adv Chronic Dis. 2021 Mar 17;12:2040622320987057. doi: 10.1177/2040622320987057. eCollection 2021.
2
Efficacy of a Subacromial Corticosteroid Injection for Persistent Pain After Arthroscopic Rotator Cuff Repair.肩峰下皮质类固醇注射治疗关节镜下肩袖修补术后持续性疼痛的疗效
Am J Sports Med. 2016 Sep;44(9):2231-6. doi: 10.1177/0363546516648326. Epub 2016 Jun 7.
3
The prevalence of neovascularity in patients clinically diagnosed with rotator cuff tendinopathy.临床上诊断为肩袖肌腱病患者的新生血管患病率。
BMC Musculoskelet Disord. 2009 Dec 21;10:163. doi: 10.1186/1471-2474-10-163.
4
Clinical and Structural Results of Rotator Cuff Repair Compared With Rotator Cuff Debridement in Arthroscopic Treatment of Calcifying Tendinitis of the Shoulder.关节镜下治疗肩钙化性肌腱炎中肩袖修复与肩袖清创术的临床和结构结果比较。
Am J Sports Med. 2021 Oct;49(12):3196-3201. doi: 10.1177/03635465211037690. Epub 2021 Sep 16.
5
Effectiveness of subacromial anti-adhesive agent injection after arthroscopic rotator cuff repair: prospective randomized comparison study.关节镜肩袖修复术后肩峰下黏连预防剂注射的有效性：前瞻性随机比较研究。
Clin Orthop Surg. 2011 Mar;3(1):55-61. doi: 10.4055/cios.2011.3.1.55. Epub 2011 Feb 15.
6
Effect of pectoralis minor relaxation on the prognosis of rotator cuff injury under arthroscopy.胸小肌松解对关节镜下肩袖损伤预后的影响。
Ann Palliat Med. 2022 Jan;11(1):77-84. doi: 10.21037/apm-21-3959.
7
One-year Patient-reported Outcomes After Arthroscopic Rotator Cuff Repair Do Not Correlate With Mild to Moderate Psychological Distress.关节镜下肩袖修复术后一年的患者报告结局与轻度至中度心理困扰无关。
Clin Orthop Relat Res. 2015 Nov;473(11):3501-10. doi: 10.1007/s11999-015-4513-5.
8
Preoperative hyaluronic acid injection modulates postoperative functional outcome in patients undergoing arthroscopic rotator cuff repair.关节镜肩袖修复术后术前注射透明质酸可调节术后功能恢复。
J Orthop Surg Res. 2020 Jun 3;15(1):204. doi: 10.1186/s13018-020-01715-5.
9
MicroRNA-29a Mitigates Subacromial Bursa Fibrosis in Rotator Cuff Lesion with Shoulder Stiffness.微小 RNA-29a 减轻伴有肩关节僵硬的肩袖损伤中肩峰下滑囊的纤维性变。
Int J Mol Sci. 2019 Nov 15;20(22):5742. doi: 10.3390/ijms20225742.
10
Does Distal Clavicle Resection Decrease Pain or Improve Shoulder Function in Patients With Acromioclavicular Joint Arthritis and Rotator Cuff Tears? A Meta-analysis.锁骨远端切除治疗肩锁关节关节炎合并肩袖撕裂患者能否减轻疼痛或改善肩部功能？一项荟萃分析。
Clin Orthop Relat Res. 2018 Dec;476(12):2402-2414. doi: 10.1097/CORR.0000000000000424.

引用本文的文献

1
Association between inflammatory proteins and rotator cuff tears: a bidirectional Mendelian randomization study.炎症蛋白与肩袖撕裂之间的关联：一项双向孟德尔随机化研究。
Sci Rep. 2025 Jul 24;15(1):26987. doi: 10.1038/s41598-025-12785-y.
2
Exploring molecular and cellular signaling pathways: Unraveling the pathogenesis of tendinopathy.探索分子和细胞信号通路：揭示肌腱病的发病机制。
J Orthop Translat. 2025 Mar 20;51:298-311. doi: 10.1016/j.jot.2025.02.003. eCollection 2025 Mar.
3
Effect of High-Dose Vitamin C on Tendon Cell Degeneration-An In Vitro Study.

本文引用的文献

1
Reactive oxygen species - sources, functions, oxidative damage.活性氧物种——来源、功能、氧化损伤
Pol Merkur Lekarski. 2020 Apr 22;48(284):124-127.
2
Loss of p53 Sensitizes Cells to Palmitic Acid-Induced Apoptosis by Reactive Oxygen Species Accumulation.p53 缺失通过活性氧积累使细胞对棕榈酸诱导的细胞凋亡敏感。
Int J Mol Sci. 2019 Dec 12;20(24):6268. doi: 10.3390/ijms20246268.
3
Hypoxia-induced microRNA-10b-3p promotes esophageal squamous cell carcinoma growth and metastasis by targeting TSGA10.缺氧诱导的微小RNA-10b-3p通过靶向TSGA10促进食管鳞状细胞癌的生长和转移。
高剂量维生素C对肌腱细胞退变的影响——一项体外研究
Int J Mol Sci. 2024 Dec 12;25(24):13358. doi: 10.3390/ijms252413358.
4
Role of oxidative stress in the concurrent development of osteoporosis and tendinopathy: Emerging challenges and prospects for treatment modalities.氧化应激在骨质疏松症和腱病并发发展中的作用：治疗方式的新挑战和前景。
J Cell Mol Med. 2024 Jul;28(13):e18508. doi: 10.1111/jcmm.18508.
5
Verapamil Attenuates the Severity of Tendinopathy by Mitigating Mitochondrial Dysfunction through the Activation of the Nrf2/HO-1 Pathway.维拉帕米通过激活Nrf2/HO-1通路减轻线粒体功能障碍，从而减轻肌腱病的严重程度。
Biomedicines. 2024 Apr 18;12(4):904. doi: 10.3390/biomedicines12040904.
6
The subacromial bursa modulates tendon healing after rotator cuff injury in rats.肩峰下滑囊可调节大鼠肩袖损伤后肌腱的愈合。
Sci Transl Med. 2024 Apr 24;16(744):eadd8273. doi: 10.1126/scitranslmed.add8273.
7
The rat as a novel model for chronic rotator cuff injuries.大鼠作为慢性肩袖损伤的新型模型。
Sci Rep. 2024 Mar 4;14(1):5344. doi: 10.1038/s41598-024-55281-5.
8
Rotator cuff tears.肩袖撕裂。
Nat Rev Dis Primers. 2024 Feb 8;10(1):8. doi: 10.1038/s41572-024-00492-3.
9
Subacromial injection of hydrolyzed collagen in the symptomatic treatment of rotator cuff tendinopathy: an observational multicentric prospective study on 71 patients.肩峰下注射水解胶原蛋白对症治疗肩袖肌腱病：一项针对71例患者的多中心前瞻性观察研究。
JSES Int. 2023 Jul 7;7(5):799-804. doi: 10.1016/j.jseint.2023.06.009. eCollection 2023 Sep.
10
Platelets Rich Plasma Increases Antioxidant Defenses of Tenocytes via Nrf2 Signal Pathway.富血小板血浆通过 Nrf2 信号通路增加腱细胞的抗氧化防御能力。
Int J Mol Sci. 2023 Aug 27;24(17):13299. doi: 10.3390/ijms241713299.
Aging (Albany NY). 2019 Nov 26;11(22):10374-10384. doi: 10.18632/aging.102462.
4
Programmed Cell-Death by Ferroptosis: Antioxidants as Mitigators.铁死亡程序性细胞死亡：抗氧化剂作为缓解剂。
Int J Mol Sci. 2019 Oct 8;20(19):4968. doi: 10.3390/ijms20194968.
5
A Unique Morphological Phenotype in Chemoresistant Triple-Negative Breast Cancer Reveals Metabolic Reprogramming and PLIN4 Expression as a Molecular Vulnerability.耐药性三阴性乳腺癌中独特的形态表型揭示了代谢重编程和 PLIN4 表达作为分子脆弱性。
Mol Cancer Res. 2019 Dec;17(12):2492-2507. doi: 10.1158/1541-7786.MCR-19-0264. Epub 2019 Sep 19.
6
Association of Patient Self-Reported Shoulder Scores to Quantitative and Semiquantitative MRI Measures of Rotator Cuff Intramuscular Fatty Infiltration: A Pilot Study.患者自评肩部评分与肩袖肌内脂肪浸润的定量和半定量 MRI 测量值的相关性：一项初步研究。
AJR Am J Roentgenol. 2019 Dec;213(6):1307-1314. doi: 10.2214/AJR.19.21218. Epub 2019 Sep 11.
7
Rehabilitation Management of Rotator Cuff Injuries in the Master Athlete.高水平运动员肩袖损伤的康复管理
Curr Sports Med Rep. 2019 Sep;18(9):330-337. doi: 10.1249/JSR.0000000000000628.
8
S100A11 functions as novel oncogene in glioblastoma via S100A11/ANXA2/NF-κB positive feedback loop.S100A11 通过 S100A11/ANXA2/NF-κB 正反馈环在胶质母细胞瘤中作为新的癌基因发挥作用。
J Cell Mol Med. 2019 Oct;23(10):6907-6918. doi: 10.1111/jcmm.14574. Epub 2019 Aug 20.
9
Treatment with fibrates is associated with higher LAL activity in dyslipidemic patients.贝特类药物治疗与血脂异常患者的 LAL 活性升高有关。
Pharmacol Res. 2019 Sep;147:104362. doi: 10.1016/j.phrs.2019.104362. Epub 2019 Jul 19.
10
HYOU1 promotes cell growth and metastasis via activating PI3K/AKT signaling in epithelial ovarian cancer and predicts poor prognosis.HYOU1 通过激活上皮性卵巢癌中的 PI3K/AKT 信号促进细胞生长和转移，并预测不良预后。
Eur Rev Med Pharmacol Sci. 2019 Jan;23(10):4126-4135. doi: 10.26355/eurrev_201901_17914.