Pagliazzi Marco, Colombo Lorenzo, Vidal-Rosas Ernesto E, Dragojević Tanja, Parfentyeva Veronika, Culver Joseph P, Konugolu Venkata Sekar Sanathana, Di Sieno Laura, Contini Davide, Torricelli Alessandro, Pifferi Antonio, Dalla Mora Alberto, Durduran Turgut
ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, 08860 Castelldefels, Barcelona, Spain.
Politecnico di Milano, Dipartimento di Fisica, 20133 Milano, Italy.
Biomed Opt Express. 2021 Feb 19;12(3):1499-1511. doi: 10.1364/BOE.418882. eCollection 2021 Mar 1.
Time (or path length) resolved speckle contrast optical spectroscopy (TD-SCOS) at quasi-null (2.85 mm) source-detector separation was developed and demonstrated. The method was illustrated by studies on the forearm muscle of an adult subject. The results have shown that selecting longer photon path lengths results in higher hyperemic blood flow change and a faster return to baseline by a factor of two after arterial cuff occlusion when compared to SCOS without time resolution. This indicates higher sensitivity to the deeper muscle tissue. In the long run, this approach may allow the use of simpler and cheaper detector arrays compared to time resolved diffuse correlation spectroscopy that are based on readily available technologies. Hence, TD-SCOS may increase the performance and decrease cost of devices for continuous non-invasive, deep tissue blood flow monitoring.
开发并演示了在准零（2.85毫米）源探测器间距下的时间（或光程长度）分辨散斑对比度光学光谱（TD-SCOS）。通过对一名成年受试者前臂肌肉的研究来说明该方法。结果表明，与没有时间分辨的SCOS相比，选择更长的光子路径长度会导致更高的充血血流变化，并且在动脉袖带阻断后恢复到基线的速度快两倍。这表明对更深层肌肉组织具有更高的敏感性。从长远来看，与基于现有技术的时间分辨扩散相关光谱相比，这种方法可能允许使用更简单、更便宜的探测器阵列。因此，TD-SCOS可能会提高连续无创深部组织血流监测设备的性能并降低成本。
