Opt Lett. 2018 Jun 1;43(11):2450-2453. doi: 10.1364/OL.43.002450.
We demonstrate time domain diffuse correlation spectroscopy at quasi-null source-detector separation by using a fast time-gated single-photon avalanche diode without the need of time-tagging electronics. This approach allows for increased photon collection, simplified real-time instrumentation, and reduced probe dimensions. Depth discriminating, quasi-null distance measurement of blood flow in a human subject is presented. We envision the miniaturization and integration of matrices of optical sensors of increased spatial resolution and the enhancement of the contrast of local blood flow changes.
我们通过使用快速时间门控单光子雪崩二极管（SPAD），在准零源-探测器分离的情况下展示了时域漫反射相关光谱学，而无需时间标记电子设备。这种方法可以增加光子收集，简化实时仪器，并减小探头尺寸。本文介绍了在人体中深度分辨、准零距离测量血流的方法。我们设想了增加空间分辨率的光学传感器矩阵的小型化和集成，并增强了局部血流变化的对比度。
