Chen Yiwei, Manzanera Silvestre, Mompeán Juan, Ruminski Daniel, Grulkowski Ireneusz, Artal Pablo
Laboratorio de Óptica, Instituto Universitario de Investigación en Óptica y Nanofísica, Universidad de Murcia, Campus de Espinardo, E-30100 Murcia, Spain.
Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University, ul. Grudziądzka 5, 87-100 Toruń, Poland.
Biomed Opt Express. 2021 Feb 23;12(3):1529-1542. doi: 10.1364/BOE.418051. eCollection 2021 Mar 1.
A three-dimensional optical coherence tomography (OCT) crystalline lens imaging method based on oblique scanning and image stitching is presented. The method was designed to increase OCT imaging volume of crystalline lens . A long-range swept-source (SS)-OCT imaging system, which can measure the entire anterior segment of eye in a single acquisition, is used to acquire one central volume and 4 extra volumes with different angles between optical axis of OCT instrument and the pupillary axis. The volumes are then stitched automatically by developed software. To show its effectiveness and verify its validity, we scanned the subjects before and after pupil dilation drops and compared the experimental results. By determining the number of voxels representing the signal from the crystalline lens in 3-D OCT images, our method can provide around 17% additional volumetric lens coverage compared with a regular imaging procedure. The proposed approach could be used clinically in early diagnosis of cortical cataract. Wider field of view offered by this method may facilitate more accurate lens biometry in its peripheral zones, which potentially contributes to understanding of lens shape modifications of the accommodating eye.
提出了一种基于斜扫描和图像拼接的三维光学相干断层扫描（OCT）晶状体成像方法。该方法旨在增加晶状体的OCT成像体积。使用一种长程扫频源（SS）-OCT成像系统，其能够在单次采集时测量眼睛的整个前段，以获取一个中心体积和4个额外体积，这些体积在OCT仪器光轴与瞳孔轴之间具有不同角度。然后通过开发的软件自动拼接这些体积。为了展示其有效性并验证其正确性，我们在滴散瞳眼药水前后对受试者进行扫描，并比较实验结果。通过确定三维OCT图像中代表晶状体信号的体素数量，与常规成像程序相比，我们的方法可以提供约17%的额外晶状体体积覆盖。所提出的方法可在临床上用于皮质性白内障的早期诊断。该方法提供的更宽视野可能有助于在其周边区域进行更精确的晶状体生物测量，这可能有助于理解调节眼中晶状体形状的改变。
