基于光学相干断层扫描技术的活体调节过程中晶状体整体形状变化
OCT-based full crystalline lens shape change during accommodation in vivo.
作者信息
Martinez-Enriquez Eduardo, Pérez-Merino Pablo, Velasco-Ocana Miriam, Marcos Susana
机构信息
Instituto de Óptica "Daza de Valdés," Consejo Superior de Investigaciones Científicas, C/Serrano 121, 28006 Madrid, Spain.
出版信息
Biomed Opt Express. 2017 Jan 18;8(2):918-933. doi: 10.1364/BOE.8.000918. eCollection 2017 Feb 1.
Abstract
The full shape of the accommodating crystalline lens was estimated using custom three-dimensional (3-D) spectral OCT and image processing algorithms. Automatic segmentation and distortion correction were used to construct 3-D models of the lens region visible through the pupil. The lens peripheral region was estimated with a trained and validated parametric model. Nineteen young eyes were measured at 0-6 D accommodative demands in 1.5 D steps. Lens volume, surface area, diameter, and equatorial plane position were automatically quantified. Lens diameter & surface area correlated negatively and equatorial plane position positively with accommodation response. Lens volume remained constant and surface area decreased with accommodation, indicating that the lens material is incompressible and the capsular bag elastic.
摘要
利用定制的三维（3-D）光谱光学相干断层扫描（OCT）和图像处理算法估计了可调节晶状体的完整形状。采用自动分割和畸变校正来构建通过瞳孔可见的晶状体区域的三维模型。晶状体周边区域通过一个经过训练和验证的参数模型进行估计。对19只年轻眼睛在0 - 6屈光度的调节需求下以1.5屈光度的步长进行测量。自动量化晶状体体积、表面积、直径和赤道平面位置。晶状体直径和表面积与调节反应呈负相关，赤道平面位置与调节反应呈正相关。晶状体体积在调节过程中保持恒定，表面积随着调节而减小，这表明晶状体物质不可压缩，囊袋具有弹性。
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