Mahto Mala, Banerjee Ayan, Biswas Bijit, Kumar Sushil, Agarwal Neeraj, Singh Prabhat Kumar
Department of Biochemistry, All India Institute of Medical Sciences Patna, Bihar, India.
Department of Community and Family Medicine, All India Institute of Medical Sciences Patna, Bihar, India.
Am J Blood Res. 2021 Feb 15;11(1):44-52. eCollection 2021.
Healthcare workers (HCWs) due to their job profile are at utmost risk of contracting severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Serological survey is an useful tool for vulnerability mapping in an infectious disease pandemic. The aim of the current study was to assess seroprevalence of IgG against SARS-CoV-2 and its determinants among HCWs of a tertiary healthcare facility of India. It was an observational study, cross-sectional in design conducted among 919 HCWs of All India Institute of Medical Sciences, Patna, Bihar, India during September, 2020. In results, IgG seroprevalence for SARS-CoV-2 among the study subjects was 13.3% [95% confidence interval (CI): 11.2-15.6%]. In univariate logistic regression analysis; gender, occupation, place of posting, use of full personal protective equipment (PPE), prior corona virus disease (COVID)-19 infection, influenza like illness (ILI), use of steam inhalation, consumption of azithromycin, zinc and vitamin C were the significant attributes which affected the IgG seropositivity for SARS-CoV-2. In the multivariable logistic regression model; occupation, place of posting, prior COVID-19 infection and ILI were significant determinants of IgG seropositivity for SARS-CoV-2. To conclude, majority of the HCWs were found to be IgG seronegative for SARS-CoV-2. Till availability of effective vaccine all of the HCWs should abide by infection prevention and control (IPC) measures to keep themselves and their contacts protected from SARS-CoV-2.
医护人员因其工作性质，感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的风险极高。血清学调查是传染病大流行期间进行易感性图谱绘制的有用工具。本研究的目的是评估印度一家三级医疗机构的医护人员中抗SARS-CoV-2 IgG的血清阳性率及其决定因素。这是一项观察性研究，于2020年9月在印度比哈尔邦巴特那市全印度医学科学研究所的919名医护人员中进行，采用横断面设计。结果显示，研究对象中SARS-CoV-2的IgG血清阳性率为13.3%[95%置信区间（CI）：11.2 - 15.6%]。在单因素逻辑回归分析中；性别、职业、工作地点、是否使用全套个人防护装备（PPE）、既往冠状病毒病（COVID）-19感染、流感样疾病（ILI）、是否使用蒸汽吸入、是否服用阿奇霉素、锌和维生素C是影响SARS-CoV-2 IgG血清阳性的重要因素。在多变量逻辑回归模型中；职业、工作地点、既往COVID-19感染和ILI是SARS-CoV-2 IgG血清阳性的重要决定因素。总之，发现大多数医护人员SARS-CoV-2的IgG血清学检测呈阴性。在有效疫苗可用之前，所有医护人员都应遵守感染预防和控制（IPC）措施，以保护自己及其接触者免受SARS-CoV-2感染。
