Chirasuthat Phatcharawat, Chirasuthat Suthep, Suchonwanit Poonkiat
Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Skin Appendage Disord. 2021 Feb;7(2):144-148. doi: 10.1159/000512950. Epub 2021 Jan 26.
Granular parakeratosis (GP) is a distinctive acquired keratotic dermatosis that is usually presented with brownish-red hyperkeratotic papules and plaques in the intertriginous areas. Follicular involvement in GP could be either extending lesions from interfollicular epithelium or originating primarily from the follicular epithelium. The latter was named follicular GP and is considered an extremely rare condition. To our knowledge, there has been one reported case so far in the literature. We herein report the second case of follicular GP in a 52-year-old Thai man presenting with multiple tiny filiform hyperkeratotic papules on his face 2 weeks after using anti-melasma cream. We also propose a classification of GP based on its distinct clinical manifestations and histopathological findings.
颗粒状角化不全症（GP）是一种独特的后天性角化性皮肤病，通常表现为在皮肤褶皱部位出现棕红色角化过度丘疹和斑块。颗粒状角化不全症中的毛囊受累可能是从毛囊间上皮扩展而来的病变，或者主要起源于毛囊上皮。后者被称为毛囊性颗粒状角化不全症，被认为是一种极其罕见的病症。据我们所知，迄今为止文献中仅报道过一例。在此，我们报告第二例毛囊性颗粒状角化不全症，患者为一名52岁的泰国男性，在使用抗黄褐斑乳膏两周后，面部出现多个微小丝状角化过度丘疹。我们还根据其独特的临床表现和组织病理学发现提出了颗粒状角化不全症的分类。
