School of Chemistry, Chemical Engineering & Life Science, Wuhan University of Technology, Wuhan, China.
Curr Med Chem. 2021 Oct 27;28(34):6990-7005. doi: 10.2174/0929867328666210331145134.
As a new type of nanomaterials, the gold nanoclusters (AuNCs) perform many special physical and chemical properties, such as large Stokes shift, relatively simple preparation, good water solubility, low toxicity, and good biocompatibility, which make them show infinite potential in various fields, especially in cancer treatment. In recent years, great progress has been made in the preparation, functionalization, and biomedical applications of the AuNCs. In this article, the latest research progress and synthesis methods of the AuNCs have been summarized, emphasizing the preparation using the "bottom- up" synthesis strategy. Furthermore, we introduced the in vivo pharmacokinetic performance of the AuNCs. In the last part, we exemplified the applications of the AuNCs in biomedicine, including photothermal therapy (PTT), bioimaging, drug delivery, and radiotherapy sensitization, which further confirmed the great potential of the AuNCs in tumor treatment.
作为一种新型的纳米材料，金纳米团簇（AuNCs）表现出许多特殊的物理和化学性质，如大斯托克斯位移、相对简单的制备、良好的水溶性、低毒性和良好的生物相容性，这使得它们在各个领域都表现出无限的潜力，尤其是在癌症治疗方面。近年来，AuNCs 的制备、功能化和生物医学应用方面取得了很大的进展。本文总结了 AuNCs 的最新研究进展和合成方法，强调采用“自下而上”的合成策略。此外，我们介绍了 AuNCs 的体内药代动力学性能。最后一部分，我们举例说明了 AuNCs 在生物医学中的应用，包括光热治疗（PTT）、生物成像、药物输送和放射治疗增敏，进一步证实了 AuNCs 在肿瘤治疗中的巨大潜力。
