Independent Researcher, Bhopal, India.
Department of Biochemistry, All India Institute of Medical Sciences. Bhopal, Madhya Pradesh-462020, India.
Curr Mol Med. 2022;22(4):336-348. doi: 10.2174/1566524021666210331151323.
Legitimate nutrition assumes a significant role in preventing diseases and, in this way, nutritional interventions establish vital strategies in the area of public health. Nutrigenomics centres on the different genes and diets in an individual and how an individual's genes influence the reaction to bioactive foodstuff. It targets considering the genetic and epigenetic interactions with nutrients to lead to a phenotypic alteration and consequently to metabolism, differentiation, or even apoptosis. Nutrigenomics and lifestyle factors play a vital role in health management and represent an exceptional prospect for the improvement of personalized diets to the individual at risk of developing diseases like cancer. Concerning cancer as a multifactorial genetic ailment, several aspects need to be investigated and analysed. Various perspectives should be researched and examined regarding the development and prognosis of breast and colon cancer. Malignant growth occurrence is anticipated to upsurge in the impending days, and an effective anticipatory strategy is required. The effect of dietary components, basically studied by nutrigenomics, looks at gene expression and molecular mechanisms. It also interrelates bioactive compounds and nutrients because of different 'omics' innovations. Several preclinical investigations demonstrate the pertinent role of nutrigenomics in breast and colon cancer, and change of dietary propensities is conceivably a successful methodology for reducing cancer risk. With the connection between the genomic profile of patients with breast or colon cancer and their supplement intake, it is conceivable to imagine an idea of personalized medicine, including nutrition and medicinal services.
合理的营养在预防疾病方面起着重要作用，因此，营养干预措施是公共卫生领域的重要策略。营养基因组学关注个体中不同的基因和饮食，以及个体的基因如何影响对生物活性食物的反应。它的目标是考虑遗传和表观遗传与营养物质的相互作用，以导致表型改变，从而影响代谢、分化，甚至细胞凋亡。营养基因组学和生活方式因素在健康管理中起着至关重要的作用，为改善个性化饮食提供了一个特殊的机会，以帮助那些有患癌症等疾病风险的人。
就癌症这种多因素遗传疾病而言，需要对多个方面进行调查和分析。对于乳腺癌和结肠癌的发展和预后，需要从多个角度进行研究和检查。预计未来恶性肿瘤的发病率将会上升，因此需要采取有效的预防策略。饮食成分的影响，主要通过营养基因组学来研究，涉及基因表达和分子机制。它还与生物活性化合物和营养物质相互关联，这得益于不同的“组学”创新。
多项临床前研究表明，营养基因组学在乳腺癌和结肠癌中具有重要作用，改变饮食偏好可能是降低癌症风险的成功方法。通过对乳腺癌或结肠癌患者的基因组特征与补充剂摄入之间的联系进行研究，可以想象出一种个性化医疗的理念，包括营养和医疗服务。
