Research Center for Functional Genomics and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 23 Marinescu Street, 40015 Cluj-Napoca, Romania.
Department of Medical Biology, Faculty of Medicine, Medical University-Plovdiv, 15-А Vassil Aprilov Blvd., Plovdiv 4000, Bulgaria; Technological Center for Emergency Medicine, 15-А Vassil Aprilov Blvd., Plovdiv 4000, Bulgaria; Center of Plant Systems Biology and Biotechnology, 139, Ruski Blvd., Plovdiv 4000, Bulgaria.
Semin Cancer Biol. 2017 Oct;46:84-106. doi: 10.1016/j.semcancer.2017.06.011. Epub 2017 Jul 1.
Nutrigenomics effects have an important role in the manipulation of dietary components for human benefit, particularly in cancer prevention or treatment. The impact of dietary components, including phytochemicals, is largely studied by nutrigenomics, looking at the gene expression and molecular mechanisms interacting with bioactive compounds and nutrients, based on new 'omics' technologies. The high number of preclinical studies proves the relevant role of nutrigenomics in cancer management. By deciphering the network of nutrient-gene connections associated with cancer, relevant data will be transposed as therapeutic interventions for this devastating pathology and for fulfilling the concept of personalized nutrition. All these are presented under the nutrigenomics canopy for a better comprehension of the relation between ingested phytochemicals and chemoprevention or chemotherapy. The profits from the nutrigenomics progress, with a particular focus on the coding and noncoding genes related to the exposure of natural compounds need to be validated. A precise attention receives the evaluation of the role of natural compounds in tandem with conventional therapy using genomic approaches, with emphasis on the capacity to inhibit drug resistance mechanisms. All these relevant nutrigenomics aspects are summarized in the present review paper. It is concluded that further nutrigenomics studies are required to improve our understanding related to the complex mechanisms of action of the natural compounds and for their appropriate application as gears in cancer therapy.
营养基因组学效应在操纵膳食成分以造福人类方面具有重要作用，特别是在癌症预防或治疗方面。营养基因组学主要研究膳食成分（包括植物化学物质）的影响，它基于新的“组学”技术，研究与生物活性化合物和营养素相互作用的基因表达和分子机制。大量的临床前研究证明了营养基因组学在癌症管理中的相关作用。通过破译与癌症相关的营养-基因连接网络，相关数据将被转化为治疗干预措施，用于治疗这种破坏性疾病，并实现个性化营养的概念。所有这些都在营养基因组学的框架下进行，以更好地理解摄入的植物化学物质与化学预防或化疗之间的关系。需要验证营养基因组学进展的收益，特别是与暴露于天然化合物相关的编码和非编码基因。使用基因组方法评估天然化合物与常规疗法联合使用的作用的精确性受到重视，重点是抑制耐药机制的能力。本综述论文总结了所有这些相关的营养基因组学方面。结论是，需要进一步进行营养基因组学研究，以提高我们对天然化合物复杂作用机制的理解，并将其作为癌症治疗的有效手段进行适当应用。
