频繁桑拿浴降低因炎症导致肺炎的风险：一项前瞻性队列研究。
Attenuated Risk of Pneumonia Due to Inflammation by Frequent Sauna Baths: A PROSPECTIVE COHORT STUDY.
作者信息
Kunutsor Setor K, Jae Sae Young, Laukkanen Jari A
机构信息
National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol, and Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Southmead Hospital, Bristol, England (Dr Kunutsor); Department of Sport Science, University of Seoul, Seoul, South Korea (Dr Jae); and Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland, and Institute of Clinical Medicine, Department of Medicine, University of Eastern Finland, Kuopio, Finland, and Central Finland Health Care District Hospital District, Department of Medicine, Jyväskylä, Finland (Dr Laukkanen).
出版信息
J Cardiopulm Rehabil Prev. 2022 Jan 1;42(1):59-63. doi: 10.1097/HCR.0000000000000598.
PURPOSE
Inflammatory pathways are involved in the pathogenesis of pneumonia. Frequent sauna sessions may reduce the risk of respiratory tract infections including pneumonia independent of inflammation. We aimed to evaluate the independent and joint associations of high-sensitivity C-reactive protein (hsCRP) and frequency of sauna bathing (FSB) with risk of pneumonia in a prospective cohort study.
METHODS
Serum hsCRP as an inflammatory marker was measured using an immunometric assay and FSB was assessed by self-reported sauna bathing habits at baseline in 2264 men aged 42-61 yr. Serum hsCRP was categorized as normal and high (≤3 and >3 mg/L, respectively) and FSB as low and high (defined as ≤1 and 2-7 sessions/wk, respectively). Multivariable-adjusted HRs (CIs) were calculated for incident pneumonia.
RESULTS
A total of 528 cases of pneumonia occurred during a median follow-up of 26.6 yr. Comparing high versus normal hsCRP, the multivariable-adjusted risk for pneumonia was HR = 1.30 (95% CI, 1.04-1.62). The corresponding risk was HR = 0.79 (95% CI, 0.66-0.95) comparing high versus low FSB. Compared with men with normal hsCRP and low FSB, high hsCRP and low FSB was associated with an increased risk of pneumonia in multivariable analysis (HR = 1.67: 95% CI, 1.21-2.29), with no evidence of an association for high hsCRP and high FSB and pneumonia (HR = 0.94: 95% CI, 0.69-1.29).
CONCLUSIONS
In a general middle-aged to older male Caucasian population, frequent sauna baths attenuated the increased risk of pneumonia due to inflammation.
目的
炎症通路参与肺炎的发病机制。频繁桑拿浴可能降低包括肺炎在内的呼吸道感染风险，且与炎症无关。我们旨在通过一项前瞻性队列研究评估高敏C反应蛋白（hsCRP）和桑拿浴频率（FSB）与肺炎风险的独立及联合关联。
方法
采用免疫比浊法测量血清hsCRP作为炎症标志物，并通过2264名年龄在42 - 61岁男性的基线自我报告桑拿浴习惯评估FSB。血清hsCRP分为正常和高（分别≤3和>3 mg/L），FSB分为低和高（分别定义为≤1和2 - 7次/周）。计算肺炎发病的多变量调整HR（CI）。
结果
在中位随访26.6年期间共发生528例肺炎病例。比较高hsCRP与正常hsCRP，肺炎的多变量调整风险为HR = 1.30（95% CI，1.04 - 1.62）。比较高FSB与低FSB，相应风险为HR = 0.79（95% CI，0.66 - 0.95）。与hsCRP正常且FSB低的男性相比，多变量分析显示hsCRP高且FSB低与肺炎风险增加相关（HR = 1.67：95% CI，1.21 - 2.29），没有证据表明hsCRP高且FSB高与肺炎有关联（HR = 0.94：95% CI，0.69 - 1.29）。
结论
在一般中年至老年男性白种人群中，频繁桑拿浴可减轻因炎症导致的肺炎风险增加。
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