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长期前瞻性队列研究:桑拿浴和心肺适能对心血管和全因死亡率风险的联合关联。

Joint associations of sauna bathing and cardiorespiratory fitness on cardiovascular and all-cause mortality risk: a long-term prospective cohort study.

机构信息

a Translational Health Sciences , Bristol Medical School, University of Bristol, Learning & Research Building (Level 1), Southmead Hospital , Bristol , UK.

b Division of Cardiology, Department of Medicine , Emory University , Atlanta , GA , USA.

出版信息

Ann Med. 2018 Mar;50(2):139-146. doi: 10.1080/07853890.2017.1387927. Epub 2017 Oct 16.

Abstract

PURPOSE

We aimed to evaluate the joint impact of cardiorespiratory fitness (CRF) and frequency of sauna bathing (FSB) on the risk of cardiovascular and all-cause mortality.

DESIGN

CRF measured by respiratory gas analyses and sauna exposure were assessed at baseline in a prospective study of 2277 men. CRF was categorized as low and high (median cut-offs) and FSB as low and high (≤2 and 3-7 sessions/week, respectively).

RESULTS

During a median follow-up of 26.1 years, 520 cardiovascular and 1124 all-cause deaths occurred. Comparing high versus low CRF, the multivariate-adjusted hazard ratios (HRs) 95% CIs for cardiovascular and all-cause mortality were 0.51 (0.41-0.63) and 0.65 (0.57-0.75), respectively. Comparing high versus low FSB, the corresponding HRs were 0.74 (0.59-0.94) and 0.84 (0.72-0.97), respectively. Compared to low CRF & low FSB, the HRs of CVD mortality for high CRF & high FSB; high CRF & low FSB; and low CRF & high FSB were 0.42 (0.28-0.62), 0.50 (0.39-0.63) and 0.72 (0.54-0.97), respectively. For all-cause mortality, the corresponding HRs were 0.60 (0.48-0.76), 0.63 (0.54-0.74) and 0.78 (0.64-0.96), respectively.

CONCLUSIONS

A combination of high CRF and frequent sauna bathing confers stronger long-term protection on mortality outcomes compared with high CRF or high FSB alone. KEY MESSAGES Cardiorespiratory fitness (CRF) and frequency of sauna bathing are independently associated with reduced mortality risk; a combination of good CRF and frequent sauna bathing may confer additional survival benefits. In a population-based prospective cohort study, a combination of high CRF levels and frequent sauna bathing (3-7 sessions per week) was associated with a substantial risk reduction in fatal cardiovascular and all-cause mortality events compared with good CRF or frequent sauna bathing alone. A combination of good fitness levels produced by aerobic exercises and frequent sauna bathing may have added health benefits and confer more protection on the risk of mortality.

摘要

目的

我们旨在评估心肺功能(CRF)和桑拿浴频率(FSB)对心血管和全因死亡率风险的联合影响。

设计

在一项对 2277 名男性进行的前瞻性研究中,通过呼吸气体分析和桑拿暴露评估了 CRF,并在基线时进行了评估。CRF 分为低和高(中位数截止值),FSB 分为低和高(分别为≤2 次和 3-7 次/周)。

结果

在中位数为 26.1 年的随访期间,发生了 520 例心血管和 1124 例全因死亡。与低 CRF 相比,高 CRF 的多变量调整后的心血管和全因死亡率的危险比(HR)95%CI 分别为 0.51(0.41-0.63)和 0.65(0.57-0.75)。与低 FSB 相比,相应的 HR 分别为 0.74(0.59-0.94)和 0.84(0.72-0.97)。与低 CRF 和低 FSB 相比,高 CRF 和高 FSB、高 CRF 和低 FSB 以及低 CRF 和高 FSB 的 CVD 死亡率 HR 分别为 0.42(0.28-0.62)、0.50(0.39-0.63)和 0.72(0.54-0.97)。对于全因死亡率,相应的 HR 分别为 0.60(0.48-0.76)、0.63(0.54-0.74)和 0.78(0.64-0.96)。

结论

与高 CRF 或高 FSB 单独相比,高 CRF 和频繁桑拿浴的结合对死亡率结果具有更强的长期保护作用。

关键信息

心肺功能(CRF)和桑拿浴频率与降低死亡风险独立相关;良好的 CRF 和频繁的桑拿浴相结合可能会带来额外的生存获益。在一项基于人群的前瞻性队列研究中,与良好的 CRF 或频繁的桑拿浴单独相比,高水平的 CRF 和频繁的桑拿浴(每周 3-7 次)相结合,可显著降低致命心血管和全因死亡事件的风险。有氧运动产生的良好健康水平和频繁的桑拿浴相结合可能会带来额外的健康益处,并对死亡率风险提供更多保护。

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