Prof. Jari Laukkanen, Institute of Clinical Medicine, Department of Medicine, University of Eastern Finland, P.O. Box 1627, FIN-70211 Kuopio, Finland, Fax: +358-17-162936, Tel +358-50-5053013, E-mail:
J Nutr Health Aging. 2023;27(5):348-353. doi: 10.1007/s12603-023-1895-1.
Elevated systolic blood pressure (SBP) is associated with an increased risk of cardiovascular disease (CVD) mortality, whereas frequent sauna bathing reduces the risk. Whether frequent sauna bathing mitigates CVD mortality among adults with elevated SBP has not been previously investigated.
We examined the interactions between SBP and frequency of sauna bathing (FSB) with the risk of CVD mortality in a cohort of Caucasian men.
The Kuopio Ischaemic Heart Disease Study cohort comprising of 2,575 men aged 42-61 years at baseline was employed for this prospective study analysis.
Resting blood pressure was measured using a standardized protocol and sauna bathing habits were assessed by a self-administered questionnaire. Systolic blood pressure was categorized as normal and high (<140 and ≥140 mmHg, respectively) and FSB as low and high (defined as ≤ 2 and 3-7 sessions/week, respectively).
A total of 744 CVD deaths were recorded during a median follow-up of 27.8 yr. Comparing high vs normal SBP, the multivariable-adjusted HR (95% CI) for CVD mortality was 1.44 (1.23-1.68). Comparing low vs high FSB, the multivariable-adjusted HR (95% CI) for CVD mortality was 1.24 (1.03-1.51). The associations persisted following mutual adjustment for each exposure. Compared with men with normal SBP-high FSB, high SBP-low FSB was associated with an increased risk of CVD mortality 1.81 (1.39-2.36), with attenuated but persisting evidence of an association for men with high SBP and high FSB 1.52 (1.06-2.16). When SBP was categorized as normal and high (<130 and ≥130 mmHg, respectively), there was no evidence of an association for men with high SBP and high FSB 1.11 (0.77-1.61).
There might be an interaction between SBP, sauna bathing and CVD mortality risk in middle-aged and older Caucasian males. Frequent sauna baths may offset the increased risk of CVD mortality in men with high-normal SBP but not elevated SBP.
收缩压升高与心血管疾病(CVD)死亡率增加相关,而频繁洗桑拿浴可降低这种风险。然而,目前尚未研究过频繁洗桑拿浴是否可以降低收缩压升高的成年人的 CVD 死亡率。
我们在一个白种人男性队列中,研究了收缩压与洗桑拿频率(FSB)之间的相互作用与 CVD 死亡率的关系。
该研究采用了库奥皮奥缺血性心脏病研究队列,共纳入了 2575 名年龄在 42-61 岁的男性。
采用标准化方案测量静息血压,通过自我管理问卷评估洗桑拿浴习惯。收缩压分为正常和升高(分别定义为<140 和≥140mmHg),FSB 分为低和高(分别定义为≤2 次/周和 3-7 次/周)。
在中位随访 27.8 年后,共记录了 744 例 CVD 死亡。与收缩压正常相比,收缩压升高(≥140mmHg)的 CVD 死亡率的多变量校正 HR(95%CI)为 1.44(1.23-1.68)。与 FSB 低相比,FSB 高的 CVD 死亡率的多变量校正 HR(95%CI)为 1.24(1.03-1.51)。在相互调整每个暴露因素后,这些关联仍然存在。与收缩压正常和 FSB 高的男性相比,收缩压升高和 FSB 低的男性的 CVD 死亡率风险增加了 1.81(1.39-2.36),而收缩压升高和 FSB 高的男性的这种关联仍然存在,但其强度有所减弱,为 1.52(1.06-2.16)。当收缩压分为正常和升高(<130 和≥130mmHg)时,收缩压升高和 FSB 高的男性与 CVD 死亡率之间没有关联,HR 为 1.11(0.77-1.61)。
在中年和老年白种男性中,收缩压、洗桑拿浴与 CVD 死亡率风险之间可能存在相互作用。频繁洗桑拿浴可能会降低收缩压正常高值男性的 CVD 死亡率风险,但对升高的收缩压没有影响。