Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA; OptoVibronex, LLC., Allentown, Pa, USA.
OptoVibronex, LLC., Allentown, Pa, USA.
J Mech Behav Biomed Mater. 2021 Jul;119:104479. doi: 10.1016/j.jmbbm.2021.104479. Epub 2021 Mar 24.
The biomechanical properties of muscles and tendons in vivo are important parameters needed to understand musculoskeletal physiology and pathology. Values of the shear moduli reported for human musculoskeletal components using elastographic techniques range from several KPa to about 100 KPa and are much lower than the tensile moduli measured in vivo which are reported to be as high as several hundred MPa at high strains. In this paper we report the results of a pilot study to measure the mechanical properties of human muscles and tendons non-invasively and non-destructively in vivo using vibrational optical coherence tomography (VOCT). VOCT is a non-invasive technique that uses audible sound and reflected infrared light to measure the resonant frequency of each tissue component. Using VOCT we report that the moduli at the biceps muscle-tendon junction are about 24-30 MPa even though moduli in other anatomic locations of muscle and tendons can vary by as much as 10 MPa. It is concluded that the modulus and stress exerted by tendons and muscles at the muscle-tendon junction are similar and that deposition of fibrous tissue at the junction will lead to reduced values of the modulus leading to tissue pathology and muscle injury.
肌肉和肌腱的生物力学特性是理解肌肉骨骼生理学和病理学所需的重要参数。使用弹性成像技术报告的人体肌肉骨骼成分的剪切模量值范围为几 kPa 到约 100 kPa，远低于体内测量的拉伸模量值，据报道，在高应变下，拉伸模量值高达数百 MPa。在本文中，我们报告了一项使用振动光学相干断层扫描（VOCT）非侵入性和非破坏性地测量人体肌肉和肌腱机械性能的初步研究结果。VOCT 是一种使用可听声音和反射红外光来测量每个组织成分的共振频率的非侵入性技术。使用 VOCT，我们报告说，二头肌肌腱交界处的模量约为 24-30 MPa，尽管肌肉和肌腱的其他解剖位置的模量可以相差 10 MPa 之多。结论是，肌腱和肌肉在肌腱交界处施加的模量和应力相似，而在交界处沉积的纤维组织将导致模量值降低，从而导致组织病理学和肌肉损伤。
