Silver F H, Shah R G
Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
OptoVibronex, LLC., Mt. Bethel, PA, USA.
Skin Res Technol. 2019 Jan;25(1):47-53. doi: 10.1111/srt.12594. Epub 2018 Jun 4.
The need to quantitatively identify the composition and organization of the macromolecular components of skin, skin lesions, scars, tumors, extracellular matrices (ECMs), and wound tissue has been a goal of researchers for many decades. A variety of studies have been recently reported applying optical coherence tomography (OCT) to image skin and cutaneous lesions.
This article describes the use of vibrational OCT to image and noninvasively characterize the macromolecular components of the ECM of skin.
We report that the major macromolecular components of skin and scar can be identified noninvasively by their characteristic moduli calculated from measurements of the resonant frequency and tissue thickness. Moduli for fat (0.03 MPa), elastic tissue (0.8 MPa), skin (2 MPa), and scar (7 MPa) can be differentiated using images and measurements of the resonant frequency and the sample thickness obtained from OCT.
Using vibrational OCT, it is possible to identify and map the location of the macromolecular components in skin and skin lesions.
数十年来，定量识别皮肤、皮肤病变、疤痕、肿瘤、细胞外基质（ECM）和伤口组织中大分子成分的组成和组织结构一直是研究人员的目标。最近有各种研究报道了应用光学相干断层扫描（OCT）对皮肤和皮肤病变进行成像。
本文描述了使用振动OCT对皮肤ECM的大分子成分进行成像和无创表征。
我们报告称，皮肤和疤痕的主要大分子成分可以通过根据共振频率和组织厚度测量计算出的特征模量进行无创识别。脂肪（0.03兆帕）、弹性组织（0.8兆帕）、皮肤（2兆帕）和疤痕（7兆帕）的模量可以通过从OCT获得的共振频率图像和测量值以及样品厚度来区分。
使用振动OCT，可以识别和绘制皮肤及皮肤病变中大分子成分的位置。
