Vasilescu Alina, Hrinczenko Borys, Swain Greg M, Peteu Serban F
International Centre of Biodynamics, Bucharest, Romania.
Division of Hematology & Oncology, Breslin Cancer Center, Michigan State University, USA.
Biosens Bioelectron. 2021 Jun 15;182:113193. doi: 10.1016/j.bios.2021.113193. Epub 2021 Mar 26.
This goal of this minireview is to introduce the reader to the area of research concerned with exhaled breath analysis for the purpose of detecting abnormal levels of physiologically-relevant chemical markers reflective of respiratory diseases. Two main two groups of sensing methods are reviewed: mass spectrometry and (bio)sensors. The discussion focuses on biosensor applications for EB and EBC analyses, which are presented in detail. The review finishes with conclusions and future perspectives, including recommendations for future near-term and long-term development of EBC biomarker sensing.
本综述的目的是向读者介绍呼气分析领域的研究,该研究旨在检测反映呼吸系统疾病的生理相关化学标志物的异常水平。本文回顾了两种主要的传感方法:质谱法和(生物)传感器。讨论重点是用于呼气和呼出气冷凝物分析的生物传感器应用,并对其进行了详细介绍。综述最后给出了结论和未来展望,包括对呼出气冷凝物生物标志物传感近期和长期未来发展的建议。