School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China; Shaanxi Engineering Research Center of Cardiovascular Drugs Screening & Analysis, Xi'an 710061, China.
School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China; Shaanxi Engineering Research Center of Cardiovascular Drugs Screening & Analysis, Xi'an 710061, China.
Food Chem. 2021 Sep 1;355:129623. doi: 10.1016/j.foodchem.2021.129623. Epub 2021 Mar 19.
Herein, the preparation of UiO-66 on frosted glass rod (FGR) was proposed through the coordination interaction of Zr-OH groups and carboxyl sites on FGR. The relative standard deviations (RSDs) of intra-batch and inter-batch were below 8.0% (n = 7). UiO-66-modified FGR (UiO-66@FGR) was applied to the extraction and monitoring of five non-steroidal anti-inflammatory drugs (NSAIDs) by coupling to novel bar sorptive extraction (BSE) with ultra-high performance liquid chromatography (UPLC). Sample volume, stirring rate, extraction time, sample pH value, desorption solvent, and desorption time were investigated. NSAIDs (ketoprofen, flurbiprofen, ibuprofen, naproxen, and diclofenac sodium) were determined at a low limit of detection (0.92 ng/mL) over a wide linear range (10-1500 ng/mL). The developed method was used to analyze NSAIDs in sheep muscle, chicken wing, and milk with recoveries of 80.8%-117.2%, RSDs < 6.5%. Fabricated UiO-66@FGR exhibited excellent reproducibility, stability, and good adsorption property towards NSAIDs in food samples.
本文通过 Zr-OH 基团与 FGR 上的羧基位点的配位相互作用，提出了在磨砂玻璃棒（FGR）上制备 UiO-66。批内和批间的相对标准偏差（RSD）均低于 8.0%（n=7）。UiO-66 修饰的 FGR（UiO-66@FGR）通过与新型棒状吸附萃取（BSE）与超高效液相色谱（UPLC）相结合，用于提取和监测五种非甾体抗炎药（NSAIDs）。考察了样品体积、搅拌速度、萃取时间、样品 pH 值、解吸溶剂和解吸时间。NSAIDs（酮洛芬、氟比洛芬、布洛芬、萘普生和双氯芬酸钠）在 10-1500ng/mL 较宽的线性范围内检测限低（0.92ng/mL）。该方法用于分析绵羊肌肉、鸡翅和牛奶中的 NSAIDs，回收率为 80.8%-117.2%，RSDs<6.5%。制备的 UiO-66@FGR 对食品样品中的 NSAIDs 表现出良好的重现性、稳定性和良好的吸附性能。
