Barrett-Catton Emma, Ross Murial L, Asuri Prashanth
Department of Bioengineering, Santa Clara University, Santa Clara, CA 95053, USA.
Polymers (Basel). 2021 Mar 11;13(6):856. doi: 10.3390/polym13060856.
Hydrogels are used for various biomedical applications due to their biocompatibility, capacity to mimic the extracellular matrix, and ability to encapsulate and deliver cells and therapeutics. However, traditional hydrogels have a few shortcomings, especially regarding their physical properties, thereby limiting their broad applicability. Recently, researchers have investigated the incorporation of nanoparticles (NPs) into hydrogels to improve and add to the physical and biochemical properties of hydrogels. This brief review focuses on papers that describe the use of nanoparticles to improve more than one property of hydrogels. Such multifunctional hydrogel nanocomposites have enhanced potential for various applications including tissue engineering, drug delivery, wound healing, bioprinting, and biowearable devices.
水凝胶因其生物相容性、模拟细胞外基质的能力以及封装和递送细胞与治疗剂的能力而被用于各种生物医学应用。然而，传统水凝胶存在一些缺点，尤其是在其物理性质方面，从而限制了它们的广泛适用性。最近，研究人员研究了将纳米颗粒（NPs）掺入水凝胶中，以改善和增强水凝胶的物理和生化性质。这篇简短的综述重点关注那些描述使用纳米颗粒来改善水凝胶多种性质的论文。这种多功能水凝胶纳米复合材料在包括组织工程、药物递送、伤口愈合、生物打印和生物可穿戴设备等各种应用中具有更大的潜力。
