急性肾损伤预后的决定因素：临床预测指标及其他
Determinants of Outcomes of Acute Kidney Injury: Clinical Predictors and Beyond.
作者信息
Abdel-Rahman Emaad M, Turgut Faruk, Gautam Jitendra K, Gautam Samir C
机构信息
Division of Nephrology, University of Virginia, Charlottesville, VA 22908, USA.
Internal Medicine/Nephrology, Faculty of Medicine, Mustafa Kemal University, Antakya/Hatay 31100, Turkey.
出版信息
J Clin Med. 2021 Mar 11;10(6):1175. doi: 10.3390/jcm10061175.
Abstract
Acute kidney injury (AKI) is a common clinical syndrome characterized by rapid impairment of kidney function. The incidence of AKI and its severe form AKI requiring dialysis (AKI-D) has been increasing over the years. AKI etiology may be multifactorial and is substantially associated with increased morbidity and mortality. The outcome of AKI-D can vary from partial or complete recovery to transitioning to chronic kidney disease, end stage kidney disease, or even death. Predicting outcomes of patients with AKI is crucial as it may allow clinicians to guide policy regarding adequate management of this problem and offer the best long-term options to their patients in advance. In this manuscript, we will review the current evidence regarding the determinants of AKI outcomes, focusing on AKI-D.
摘要
急性肾损伤（AKI）是一种常见的临床综合征，其特征为肾功能迅速受损。多年来，AKI及其严重形式即需要透析的急性肾损伤（AKI-D）的发病率一直在上升。AKI的病因可能是多因素的，并且与发病率和死亡率的增加密切相关。AKI-D的结局可能各不相同，从部分或完全恢复到转变为慢性肾脏病、终末期肾脏病，甚至死亡。预测AKI患者的结局至关重要，因为这可能使临床医生能够指导有关该问题适当管理的策略，并提前为患者提供最佳的长期选择。在本手稿中，我们将回顾有关AKI结局决定因素的当前证据，重点关注AKI-D。
相似文献
1
Determinants of Outcomes of Acute Kidney Injury: Clinical Predictors and Beyond.急性肾损伤预后的决定因素：临床预测指标及其他
J Clin Med. 2021 Mar 11;10(6):1175. doi: 10.3390/jcm10061175.
2
Long-Term Outcomes and Associated Risk Factors of Post-Hospitalization Dialysis-Dependent Acute Kidney Injury Patients.出院后依赖透析的急性肾损伤患者的长期结局及相关危险因素
Nephron. 2017;137(2):105-112. doi: 10.1159/000478277. Epub 2017 Jul 29.
3
Non-recovery from dialysis-requiring acute kidney injury and short-term mortality and cardiovascular risk: a cohort study.透析依赖的急性肾损伤未能恢复与短期死亡率和心血管风险：一项队列研究。
BMC Nephrol. 2018 Jun 11;19(1):134. doi: 10.1186/s12882-018-0924-3.
4
Changing incidence and outcomes following dialysis-requiring acute kidney injury among critically ill adults: a population-based cohort study.透析治疗急性肾损伤在危重症成人中的发病率和结局变化：一项基于人群的队列研究。
Am J Kidney Dis. 2015 Jun;65(6):870-7. doi: 10.1053/j.ajkd.2014.10.017. Epub 2014 Dec 18.
5
The impact of continuous renal replacement therapy on renal outcomes in dialysis-requiring acute kidney injury may be related to the baseline kidney function.持续肾脏替代疗法对需要透析的急性肾损伤患者肾脏预后的影响可能与基线肾功能有关。
BMC Nephrol. 2017 May 3;18(1):150. doi: 10.1186/s12882-017-0564-z.
6
Dialysis requirement, long-term major adverse cardiovascular events (MACE) and all-cause mortality in hospital acquired acute kidney injury (AKI): a propensity-matched cohort study.医院获得性急性肾损伤（AKI）的透析需求、长期主要不良心血管事件（MACE）及全因死亡率：一项倾向评分匹配队列研究
J Nephrol. 2016 Dec;29(6):847-855. doi: 10.1007/s40620-016-0321-6. Epub 2016 Jun 15.
7
Predictors and Outcomes of Post-Hospitalization Dialysis Dependent Acute Kidney Injury.出院后依赖透析的急性肾损伤的预测因素及结局
Nephron. 2015;131(3):185-90. doi: 10.1159/000441607. Epub 2015 Nov 3.
8
Nationwide epidemiology and prognosis of dialysis-requiring acute kidney injury (NEP-AKI-D) study: Design and methods.全国需要透析的急性肾损伤（NEP-AKI-D）研究：设计与方法。
Nephrology (Carlton). 2016 Sep;21(9):758-64. doi: 10.1111/nep.12670.
9
Renal recovery after severe acute renal injury.严重急性肾损伤后的肾功能恢复
Eur J Med Res. 2008 Dec 3;13(12):552-6.
10
Long-term outcomes after extracorporeal membrane oxygenation in patients with dialysis-requiring acute kidney injury: A cohort study.接受体外膜肺氧合治疗的需要透析的急性肾损伤患者的长期预后：一项队列研究。
PLoS One. 2019 Mar 13;14(3):e0212352. doi: 10.1371/journal.pone.0212352. eCollection 2019.
引用本文的文献
1
Renal drug dosing practices and clinical outcomes in patients with kidney disease admitted at two referral hospitals in Northwest Ethiopia.埃塞俄比亚西北部两家转诊医院收治的肾病患者的肾脏药物给药实践及临床结果
BMC Nephrol. 2025 Aug 20;26(1):474. doi: 10.1186/s12882-025-04410-x.
2
Methotrexate-related drug reactions on kidneys and liver in rheumatoid arthritis: an analysis of spontaneous reports in EudraVigilance.甲氨蝶呤在类风湿关节炎中引起的肾脏和肝脏药物反应：基于欧洲药物警戒系统自发报告的分析
Arthritis Res Ther. 2025 Apr 5;27(1):80. doi: 10.1186/s13075-025-03551-6.
3
Acute Kidney Injury in Autoimmune-Mediated Rheumatic Diseases.自身免疫介导的风湿性疾病中的急性肾损伤
J Clin Med Res. 2025 Feb;17(2):67-75. doi: 10.14740/jocmr6149. Epub 2025 Feb 13.
4
Can Novel Biomarkers Effectively Predict Acute Kidney Injury in Liver or Kidney Transplant Recipients?新型生物标志物能否有效预测肝或肾移植受者的急性肾损伤？
Int J Mol Sci. 2024 Nov 10;25(22):12072. doi: 10.3390/ijms252212072.
5
Acute Kidney Injury and Its Association With Dementia and Specific Dementia Types: Findings From a Population-Based Study in Sweden.急性肾损伤及其与痴呆和特定类型痴呆的关联：来自瑞典一项基于人群的研究结果。
Neurology. 2024 Sep 24;103(6):e209751. doi: 10.1212/WNL.0000000000209751. Epub 2024 Aug 22.
6
A Combined Biomarker That Includes Plasma Fibroblast Growth Factor 23, Erythropoietin, and Klotho Predicts Short- and Long-Term Morbimortality and Development of Chronic Kidney Disease in Critical Care Patients with Sepsis: A Prospective Cohort.一种包含血浆成纤维细胞生长因子 23、促红细胞生成素和 Klotho 的联合生物标志物可预测重症监护脓毒症患者的短期和长期病死率和慢性肾脏病的发生：一项前瞻性队列研究。
Biomolecules. 2023 Oct 3;13(10):1481. doi: 10.3390/biom13101481.
7
The benefits of early continuous renal replacement therapy in critically ill patients with acute kidney injury at high-altitude areas: a retrospective multi-center cohort study.高海拔地区危重症急性肾损伤患者早期持续肾脏替代治疗的获益：一项回顾性多中心队列研究。
Sci Rep. 2023 Sep 9;13(1):14882. doi: 10.1038/s41598-023-42003-6.
8
Optimum Post-Discharge Care of Acute Kidney Injury (AKI) Survivors.急性肾损伤（AKI）幸存者的最佳出院后护理
J Clin Med. 2022 Oct 25;11(21):6277. doi: 10.3390/jcm11216277.
9
Association of Intradialytic Hypotension and Ultrafiltration with AKI-D Outcomes in the Outpatient Dialysis Setting.门诊透析环境中透析期间低血压和超滤与急性肾损伤-透析相关结局的关联
J Clin Med. 2022 Jun 1;11(11):3147. doi: 10.3390/jcm11113147.
10
Correlation of Kidney Size on Computed Tomography with GFR, Creatinine and HbA1C for an Accurate Diagnosis of Patients with Diabetes and/or Chronic Kidney Disease.计算机断层扫描测量的肾脏大小与肾小球滤过率、肌酐及糖化血红蛋白的相关性，用于准确诊断糖尿病和/或慢性肾脏病患者
Diagnostics (Basel). 2021 Apr 27;11(5):789. doi: 10.3390/diagnostics11050789.
本文引用的文献
1
The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study.新型冠状病毒肺炎与急性肾损伤的关联：一项多中心队列研究，疾病严重程度无关。
Am J Kidney Dis. 2021 Apr;77(4):490-499.e1. doi: 10.1053/j.ajkd.2020.12.007. Epub 2021 Jan 8.
2
Dynamics of salivary markers of kidney functions in acute and chronic kidney diseases.唾液标志物在急性和慢性肾脏疾病中的肾脏功能动力学。
Sci Rep. 2020 Dec 4;10(1):21260. doi: 10.1038/s41598-020-78209-1.
3
Role of Renal Replacement Therapy During the Peri-Transplant Period of Heart Transplantation.心脏移植围手术期肾脏替代治疗的作用。
Ann Transplant. 2020 Nov 24;25:e925648. doi: 10.12659/AOT.925648.
4
Creatinine-Cystatin C Ratio and Mortality in Patients Receiving Intensive Care and Continuous Kidney Replacement Therapy: A Retrospective Cohort Study.肌酸酐-胱抑素 C 比值与接受重症监护和连续性肾脏替代治疗患者的死亡率：一项回顾性队列研究。
Am J Kidney Dis. 2021 Apr;77(4):509-516.e1. doi: 10.1053/j.ajkd.2020.08.014. Epub 2020 Oct 21.
5
The Relationship between AKI and CKD in Patients with Type 2 Diabetes: An Observational Cohort Study.2 型糖尿病患者急性肾损伤与慢性肾脏病的关系：一项观察性队列研究。
J Am Soc Nephrol. 2021 Jan;32(1):138-150. doi: 10.1681/ASN.2020030323. Epub 2020 Sep 18.
6
Nephrologist Follow-Up Care of Patients With Acute Kidney Disease Improves Outcomes: Taiwan Experience.肾病学家对急性肾脏病患者的随访护理可改善预后：台湾经验。
Value Health. 2020 Sep;23(9):1225-1234. doi: 10.1016/j.jval.2020.01.024. Epub 2020 Aug 6.
7
Renin-angiotensin aldosterone inhibitor use at hospital discharge among patients with moderate to severe acute kidney injury and its association with recurrent acute kidney injury and mortality.中重度急性肾损伤患者出院时肾素-血管紧张素-醛固酮抑制剂的使用情况及其与急性肾损伤复发和死亡率的关联。
Kidney Int. 2021 May;99(5):1202-1212. doi: 10.1016/j.kint.2020.08.022. Epub 2020 Sep 8.
8
Changes in Novel AKI Biomarkers after Exercise. A Systematic Review.运动后新型急性肾损伤生物标志物的变化。系统评价。
Int J Mol Sci. 2020 Aug 7;21(16):5673. doi: 10.3390/ijms21165673.
9
Exploring reasons for state-level variation in incidence of dialysis-requiring acute kidney injury (AKI-D) in the United States.探讨美国各州透析相关性急性肾损伤（AKI-D）发病率差异的原因。
BMC Nephrol. 2020 Aug 10;21(1):336. doi: 10.1186/s12882-020-02000-7.
10
Long-Term Outcomes and Risk Factors of Renal Failure Requiring Dialysis after Heart Transplantation: A Nationwide Cohort Study.心脏移植后需要透析的肾衰竭的长期结局和危险因素：一项全国性队列研究。
J Clin Med. 2020 Jul 31;9(8):2455. doi: 10.3390/jcm9082455.
Zotero 插件