Kundel H L, Shetty A, Joseph P M, Summers R M, Kassab E A, Moore B
Department of Radiology, University of Pennsylvania, Philadelphia 19104.
Magn Reson Med. 1988 Apr;6(4):381-9. doi: 10.1002/mrm.1910060403.
Coronal proton and sodium images of control rats and rats with either increased permeability edema produced by intravenous alloxan (300 mg/kg) or increased pressure edema produced by saline infusion (2 ml/min) were obtained. Axial chest CT images were used to monitor the development of pulmonary edema. Immediately after the imaging session compartmental lung water was measured gravimetrically. The sodium and proton imagings were done sequentially in a 31-cm-bore 1.9-T magnet without moving the animal. The anatomical boundaries of the lung on the proton images were transferred to the sodium images for calculation of the average sodium signal intensity which was determined by extrapolating the mean values from five echoes to time zero. The sodium signal intensity was correlated (r = 0.7) with the total water fraction. There was poor correlation (r = 0.56) with the extravascular water due to confounding by the sodium vascular signal.
获取了对照组大鼠以及通过静脉注射四氧嘧啶（300毫克/千克）产生通透性增加性水肿或通过输注生理盐水（2毫升/分钟）产生压力性水肿的大鼠的冠状位质子和钠图像。使用胸部轴向CT图像监测肺水肿的发展。成像 session 结束后立即通过重量法测量肺组织含水量。钠成像和质子成像在一台31厘米孔径的1.9-T磁体中依次进行，动物无需移动。将质子图像上肺的解剖边界转移到钠图像上，以计算平均钠信号强度，该强度通过将五个回波的平均值外推到时间零点来确定。钠信号强度与总水分含量相关（r = 0.7）。由于钠血管信号的干扰，与血管外水分的相关性较差（r = 0.56）。
